Reactions of 3-Hydroxy-2-phenyl-1-benzo[]isoindol-1-one: A Route to 3-Hydroxy-/3-anilinobenzo[]indan-1-ones and Benzo[]phthalazin-1(2)-ones.

New hydroxy- and anilinoindanone derivatives and were synthesized starting from 3-hydroxybenzo[]isoindolinone via the addition of alkyllithium (-BuLi, -BuLi, MeLi or -PrLi) to the carbonyl group, followed by lactam ring opening and, finally, an intramolecular cyclization leading to target compounds. The same starting material was used for the preparation of the new benzo[]phthalazinone derivatives through multi-step reactions. The target derivative was obtained from the corresponding bromolactam by the Buchwald-Hartwig amination. Structures of the obtained compounds were confirmed by the NMR spectra.