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Computational Bioprospecting Guggulsterone against ADP Ribose Phosphatase of SARS-CoV-2. | LitMetric

AI Article Synopsis

  • COVID-19, caused by the SARS-CoV-2 virus, was declared a global health emergency by the WHO on March 11, 2020, and there are no fully effective treatments available yet.
  • The management of COVID-19 relies largely on prior research from related viruses like SARS-CoV and MERS-CoV, while natural products like plants are recognized for their potential to enhance healthcare and preventive measures.
  • The study identified guggulsterone as a promising herbal compound that stabilizes the SARS-CoV-2 ADP Ribose Phosphatase enzyme, suggesting its potential development into a safe treatment for COVID-19 in future clinical studies.

Article Abstract

Coronavirus Disease-2019 (COVID-19) is a highly contagious disease caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). The World Health Organization (WHO) classified the disease a as global public health hazard on 11 March 2020. Currently, there are no adequate measures to combat viral infections, including COVID-19, and the medication guidelines for the management of COVID-19 are dependent on previous findings from SARS-CoV and MERS-CoV research. Natural products have achieved widespread acceptance around the world as a means of enhancing healthcare and disease prevention. Plants are a potential source of antiviral factors such as flavonoids, phenolic acids, terpenoids, and others. Some of these agents exhibit a broad spectrum of antiviral activity. This study aimed to screen herbal leads for possible inhibitors of the SARS-CoV-2 ADP Ribose Phosphatase enzyme (ARP). Guggulsterone was found to be highly stabilized within the active site of the viral ARP enzyme by molecular dynamic simulation with very little fluctuation throughout the simulation timeframe of 100 ns. Thus, guggulsterone can be further used to develop a safe and competent medication for evolving therapy against SARS-CoV-2 in post-preclinical and clinical trials.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739500PMC
http://dx.doi.org/10.3390/molecules27238287DOI Listing

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