AI Article Synopsis
- - PTLD, a rare but serious complication affecting about 5% of transplant patients, can be particularly difficult to diagnose when it presents as isolated central nervous system (CNS) lesions, as symptoms often mimic other conditions.
- - This case study discusses a 72-year-old woman who developed severe headaches and confusion 11 years post-kidney transplant, leading to imaging that revealed abnormal brain swelling, which required surgery for further investigation.
- - The diagnosis was confirmed as polymorphic type PTLD, highlighting the importance of monitoring immunosuppressive treatments and the need for prompt diagnosis to improve survival chances for affected patients.
Article Abstract
Background: Post-transplant lymphoproliferative disorders (PTLD) are rare immunosuppression complications affecting 5% of transplant patients. Isolated central nervous system (CNS)-PTLD without nodal or extra-nodal organ involvement is rarely reported and is difficult to diagnose due to the non-specific clinical manifestations and imaging features overlapping with other common CNS lesions.
Case Presentation: We present a case of a 72-year-old female subjected to a renal transplant 11 years ago with progressively worsening headaches and confusion. Imaging revealed vasogenic edema in the left frontal and bilateral temporal lobes. She was subjected to a craniotomy and excisional biopsy to obtain tissue for diagnostic and therapeutic interventions. Pathology examination showed atypical EBV-positive lymphoplasmacytic infiltrate, consistent with Polymorphic type PTLD.
Conclusions: Patients diagnosed with PTLD need to have close monitoring of immunosuppressive medications while in the hospital. Early diagnosis is essential for patient survival with PTLD, as their health can deteriorate fast.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739215 | PMC |
| http://dx.doi.org/10.3390/jcm11237058 | DOI Listing |
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