Background: How molecular profiles are associated with tumor microenvironment (TME) in high-grade serous ovarian cancer (HGSOC) is incompletely understood. Therefore, we analyzed the TME and molecular profiles of HGSOC and assessed their associations with overall survival (OS).
Methods: Patients with advanced-stage HGSOC treated in three Dutch hospitals between 2008-2015 were included. Patient data were collected from medical records. mutation, promotor methylation analyses, and copy number variations were used to define molecular profiles. Immune cells were assessed with immunohistochemical staining.
Results: 348 patients were categorized as mutation (m) (m or promotor methylation) (30%), non- mutated HRD (19%), Cyclin E1 ()-amplification (13%), non-mut HRD and -amplification (double classifier) (20%), and no specific molecular profile (NSMP) (18%). m showed highest immune cell densities and -amplification lowest. m showed the most favorable OS (52.5 months), compared to non-mut HRD (41.0 months), -amplification (28.0 months), double classifier (27.8 months), and NSMP (35.4 months). Higher immune cell densities showed a favorable OS compared to lower, also within the profiles. CD8+, CD20+, and CD103+ cells remained associated with OS in multivariable analysis.
Conclusions: Molecular profiles and TME are associated with OS. TME differs per profile, with higher immune cell densities showing a favorable OS, even within the profiles. HGSOC does not reflect one entity but comprises different entities based on molecular profiles and TME.
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| http://dx.doi.org/10.3390/cancers14235965 | DOI Listing |
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