Increasing evidence suggests that the gut microbiota may impact colorectal cancer (CRC) development and progression. In this study, the tumour colonisation of two CRC-associated bacteria, and , was studied in relation to patient survival in a cohort of 257 CRC patients. Colonisation of and was analysed in fresh frozen tumour tissue (n = 112) and in faeces (n = 250) by qPCR. When analysing tumour tissues, both and were found to be associated with decreased five-year cancer-specific survival, an association that remained significant in multivariable analysis for . Furthermore, we found significant associations of high levels of and with tumour molecular characteristics, i.e., tumours mutated in , and tumours of the MSI subtype. The analysis of faecal samples showed weaker associations with prognosis and tumour molecular characteristics. In conclusion, our findings support a novel association of tumour colonisation of with decreased patient survival. A better understanding of the role of the gut microbiota in CRC might contribute to the advancement of prognostic tools and new targets for therapy.
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| http://dx.doi.org/10.3390/cancers14235937 | DOI Listing |
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