AI Article Synopsis
- The aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (ARNT) are transcription factors that help manage the body's response to various chemicals, but their roles in detoxification are not fully understood.
- A study found that these receptors were notably expressed in the midgut and Malpighian tubules of adult organisms and showed increased activity after exposure to certain terpenoids.
- Silencing these receptors heightened the organism's vulnerability to specific chemicals and reduced detoxification enzyme activity, suggesting they play a critical role in detoxification processes and insect toxicology.
Article Abstract
The aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (ARNT) belong to the bHLH-PAS (basic Helix-Loop-Helix-Period/ARNT/Single-minded) family of transcription factors, which participate in the sensing and transmitting stimuli of exogenous and endogenous chemical substances, and subsequently activates genes transcription involved in various detoxification and physiological functions. However, they have not been identified in and their roles in the detoxification metabolism are unclear. In the present study, and of were characterized. Spatiotemporal expression profiling indicated that and were highly expressed in the adult and larval stages of and mainly expressed in the midgut and Malpighian tubules of adults. Additionally, the expression of and significantly increased after exposure to (-)-𝛽-pinene, (+)-3-carene, and (±)-limonene. Silencing and increased the susceptibility of to (-)-𝛽-pinene, (+)-3-carene, and (±)-limonene, and the activities of detoxification enzyme were also remarkably reduced. Moreover, and were significantly down-regulated after injections of and in the male and female adults, with the expression of decreasing by higher than 70%. The present study revealed that the transcription factors and of were induced by terpenoids and participated in the regulation of 1 expression, which was associated with 's susceptibility to (-)-𝛽-pinene and (±)-limonene. These results may provide a theoretical basis for the integrated control of and improve our comprehension of insect toxicology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736963 | PMC |
| http://dx.doi.org/10.3390/cells11233856 | DOI Listing |
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