Combining TEMPO and methyl undecenoate to produce an effective anti-mosquito compound with convenient spin-labeling.

Exp Parasitol

United States Department of Agriculture, Agricultural Research Service, National Center for Agricultural Utilization Research, Crop Bioprotection Research Unit, 1815 N. University Street, Peoria, IL, 61604, USA. Electronic address:

Published: January 2023

A general method to spin-label a fatty acid was demonstrated as well as an assay of the effectiveness of methyl 10-undecenoate and the spin-labeled version, against the larvae of Aedes aegypti. The LCs were 66 and 58 μL/120 mL (55 and 48 ppm) respectively, and the LCs were 108 and 90 μL/120 mL (113 and 90) ppm. This shows that the spin-label has very little effect on the larvicidal activity of the compound. This opens the possibility of the use of spin-labeling as a tool to determine mechanisms of larvicidal effectiveness, as it can be employed without altering the system under study.

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http://dx.doi.org/10.1016/j.exppara.2022.108440DOI Listing

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