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A preliminary ex vivo diffusion tensor imaging study of distinct aortic morphologies.
J Anat
January 2025
Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Changes in the microstructure of the aortic wall precede the progression of various aortic pathologies, including aneurysms and dissection. Current clinical decisions with regards to surgical planning and/or radiological intervention are guided by geometric features, such as aortic diameter, since clinical imaging lacks tissue microstructural information. The aim of this proof-of-concept work is to investigate a non-invasive imaging method, diffusion tensor imaging (DTI), in ex vivo aortic tissue to gain insights into the microstructure.
View Article and Find Full Text PDFObstructive sleep apnea and structural and functional brain alterations: a brain-wide investigation from clinical association to genetic causality.
BMC Med
January 2025
Sleep Medicine Center, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, NO.28 Qiaozhong Mid Road, Guangzhou, Guangdong, 510160, China.
Background: Obstructive sleep apnea (OSA) is linked to brain alterations, but the specific regions affected and the causal associations between these changes remain unclear.
Methods: We studied 20 pairs of age-, sex-, BMI-, and education- matched OSA patients and healthy controls using multimodal magnetic resonance imaging (MRI) from August 2019 to February 2020. Additionally, large-scale Mendelian randomization analyses were performed using genome-wide association study (GWAS) data on OSA and 3935 brain imaging-derived phenotypes (IDPs), assessed in up to 33,224 individuals between December 2023 and March 2024, to explore potential genetic causality between OSA and alterations in whole brain structure and function.
Research on noise-induced hearing loss based on functional and structural MRI using machine learning methods.
Sci Rep
January 2025
Imaging Department, Yantaishan Hospital, Yantai, China.
Noise-induced hearing loss (NIHL) is a common occupational condition. The aim of this study was to develop a classification model for NIHL on the basis of both functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging (sMRI) by applying machine learning methods. fMRI indices such as the amplitude of low-frequency fluctuation (ALFF), fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), degree of centrality (DC), and sMRI indices such as gray matter volume (GMV), white matter volume (WMV), and cortical thickness were extracted from each brain region.
View Article and Find Full Text PDFExploring Rhinophyma treatment: An observational study comparing the results of the cold blade technique and ablative fractional CO2-laser.
J Plast Reconstr Aesthet Surg
January 2025
Department of Burns and Plastic Surgery, St Helens and Knowsley NHS Trust (STHK), Warrington Road, Prescot, Merseyside L35 5DR, UK.
Use of multi-modal non-contrast MRI to predict functional outcomes after stroke: A study using DP-pCASL, DTI, NODDI, and MAP MRI.
Neuroimage Clin
January 2025
Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, United States. Electronic address:
Purpose: This study aims to assess whether water exchange rate (k), a surrogate for blood-brain barrier (BBB) permeability, is associated with functional outcomes in patients with acute ischemic stroke (AIS).
Methods: We studied 22 AIS patients enrolled from 1/2022 to 4/2024 who underwent multi-modal non-contrast imaging on a 3.0-Tesla scanner, including DP-pCASL, DTI, NODDI and MAP imaging.
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