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Post-SARS-CoV-2 infection and post-vaccine-related neurological complications share clinical features and the same positivity to anti-ACE2 antibodies.
Front Immunol
August 2024
Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Ospedale Policlinico San Martino, Genova, Italy.
Introduction: A potential overlap in symptoms between post-acute COVID-19 syndrome and post-COVID-19 vaccination syndrome has been noted. We report a paired description of patients presenting with similar manifestations involving the central (CNS) or peripheral nervous system (PNS) following SARS-CoV-2 infection or vaccination, suggesting that both may have triggered similar immune-mediated neurological disorders in the presence of anti-idiotype antibodies directed against the ACE2 protein.
Patients And Methods: Four patients exhibited overlapping neurological manifestations following SARS-CoV-2 infection or vaccination: radiculitis, Guillain-Barré syndrome, and MRI-negative myelitis, respectively, sharing positivity for anti-ACE2 antibodies.
MRI-negative myelitis associated with MOG-IgG antibody: A case report and literature reviews.
eNeurologicalSci
December 2023
Department of Neurology, Gil Medical Center, Gachon University College of Medicine, 21, Namdong-daero 774beon-gil, Namdong-gu, Incheon, Republic of Korea.
Article Synopsis
- MOGAD can sometimes present as myelitis, even when the spine MRI appears normal, which is uncommon according to some case reports.
- A specific case is described where the patient had symptoms of myelitis, but their MRI did not show any abnormalities, while they tested positive for anti-MOG-IgG antibodies in their blood.
- The patient experienced significant recovery after receiving high doses of methylprednisolone treatment.
The case report of MOG and NMDAR IgG double positive encephalitis treated with subcutaneous ofatumumab.
Front Immunol
September 2023
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
The phenotypic spectrum of myelin oligodendrocyte glycoprotein (MOG)- IgG-associated disorders (MOGAD) has broadened in the past few years, and atypical phenotypes are increasingly recognized. Isolated seizures and MRI-negative brainstem and cerebellar symptoms or encephalitis have rarely been reported as a feature of MOGAD and represent a diagnostic challenge. Meanwhile, the coexistence of MOG IgG and other CNS autoimmune antibodies is infrequent.
View Article and Find Full Text PDFMRI-Negative MOG Antibody-Associated Disease in Meningitis.
Indian J Pediatr
February 2023
Department of Neurology, Amrita Institute of Medical Sciences and Research Center, Kochi, Kerala, India.
Relapsing MRI-negative myelitis associated with myelin-oligodendrocyte glycoprotein autoantibodies: a case report.
BMC Neurol
August 2022
Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.
Background: Serum antibodies to myelin-oligodendrocyte glycoprotein (MOG) are biomarkers of MOG-IgG-associated disorder (MOGAD), a demyelinating disease distinct from both multiple sclerosis and aquaporin-4-IgG neuromyelitis optica spectrum disorder. The phenotype of MOGAD is broad and includes optic neuritis, transverse myelitis, and acute demyelinating encephalomyelitis. Myelitis is common with MOGAD and typically results in acute and severe disability, although prospects for recovery are often favorable with prompt immunotherapy.
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