AI Article Synopsis
- Circular RNAs (CircRNAs) are a unique type of noncoding RNAs created through a process called backsplicing, found in many organisms and involved in various biological functions.
- Although there has been significant research into how circRNAs are formed and their roles in diseases, there's limited understanding of how they are degraded, with only a few specific degradation pathways identified.
- This overview aims to provide essential information about circRNAs and their degradation mechanisms, while also inspiring future research in this area for scholars interested in circRNA studies.
Article Abstract
Circular RNAs (CircRNAs) are a class of noncoding RNAs formed by backsplicing during cotranscriptional and posttranscriptional processes, and they widely exist in various organisms. CircRNAs have multiple biological functions and are associated with the occurrence and development of many diseases. While the biogenesis and biological function of circRNAs have been extensively studied, there are few studies on circRNA degradation and only a few pathways for specific circRNA degradation have been identified. Here we outline basic information about circRNAs, summarize the research on the circRNA degradation mechanisms and discusses where this field might head, hoping to provide some inspiration and guidance for scholars who aim to study the degradation of circRNAs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734648 | PMC |
| http://dx.doi.org/10.1038/s42003-022-04262-3 | DOI Listing |
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