AI Article Synopsis
- A novel flow injection-chemiluminescence (FI-CL) method was developed to measure pioglitazone hydrochloride (PG-HCl) based on its enhancement of a specific chemiluminescence reaction in sulfuric acid.
- The optimal conditions for the assay include particular concentrations of the reagents and a specific flow rate, ensuring precise and accurate measurement of PG-HCl.
- This method demonstrated a strong linear response for PG-HCl detection, with good limits of detection and quantification, and it effectively quantified PG-HCl in pharmaceutical tablets with high recovery rates.
Article Abstract
A novel flow injection-chemiluminescence (FI-CL) approach is proposed for the assay of pioglitazone hydrochloride (PG-HCl) based on its enhancing influence on the tris(2,2'-bipyridyl)ruthenium(II)-silver(III) complex (Ru(bipy) -DPA) CL system in sulfuric acid medium. The possible CL reaction mechanism is discussed with CL and ultraviolet (UV) spectra. The optimum experimental conditions were found as: Ru(bipy) , 5.0 × 10 M; sulfuric acid, 1.0 × 10 M; diperiodatoargentate(III) (DPA), 1.0 × 10 M; potassium hydroxide, 1.0 × 10 M; flow rate 4.0 ml min for each flow stream and sample loop volume, 180 μl. The CL intensity of PG-HCl was linear in the range of 1.0 × 10 to 5.0 mg L (R = 0.9998, n = 10) with limit of detection [LOD, signal-to-noise ratio (S/N) = 3] of 2.2 × 10 mg L , limit of quantification (LOQ, S/N = 10) of 6.7 × 10 mg L , relative standard deviation (RSD) of 1.0 to 3.3% and sampling rate of 106 h . The methodology was satisfactorily used to quantify PG-HCl in pharmaceutical tablets with recoveries ranging from 93.17 to 102.77 and RSD from 1.9 to 2.8%.
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