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Maternal fiber deprivation alters microbiota in offspring, resulting in low-grade inflammation and predisposition to obesity. | LitMetric

Maternal fiber deprivation alters microbiota in offspring, resulting in low-grade inflammation and predisposition to obesity.

Cell Host Microbe

Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. Electronic address:

Published: January 2023

AI Article Synopsis

Article Abstract

Diet, especially fiber content, plays an important role in sustaining a healthy gut microbiota, which promotes intestinal and metabolic health. Another major determinant of microbiota composition is the specific microbes that are acquired early in life, especially maternally. Consequently, we hypothesized that alterations in maternal diet during lactation might lastingly impact the microbiota composition and health status of offspring. Accordingly, we observed that feeding lactating dams low-fiber diets resulted in offspring with lasting microbiota dysbiosis, including reduced taxonomic diversity and increased abundance of Proteobacteria species, despite the offspring consuming a fiber-rich diet. Such microbiota dysbiosis was associated with increased encroachment of bacteria into inner mucus layers, low-grade gut inflammation, and a dramatically exacerbated microbiota-dependent increase in adiposity following exposure to an obesogenic diet. Thus, maternal diet is a critical long-lasting determinant of offspring microbiota composition, impacting gut health and proneness to obesity and its associated disorders.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850817PMC
http://dx.doi.org/10.1016/j.chom.2022.10.014DOI Listing

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