Background: Although clozapine is much researched in western literature, a review on Indian research on clozapine published in 2010 reported limited data and need for further research in this area.
Aim: We aimed to conduct a systematic review of research on clozapine from India from 2010 to mid-2022 and also compare the same with research output before 2010.
Methodology: A systematic various search engines, i.e., PUBMED, Medknow, Hinari and Google Scholar was done using the key words clozapine and India. Published articles with clozapine in the title and having an author from India, published during 2010 to July 2022 were included.
Results: Initial Internet and hand searches yielded 280 articles, out of which 126 articles were excluded due to various reasons and 154 articles, were included for the review. This included 84 case reports, 49 original articles, 11 review articles and 10 letters to the editor as comments. We found an increase in the number of publications during the period of 2010-2022 compared to 1997-2009 in all types of publications. Over the years a significant proportion of the articles focused on various side effects of clozapine, factors associated with response and non-response to clozapine and evaluation of outcomes other than efficacy/effectiveness. However, all the studies were limited to a single centre with no multicentric studies on clozapine.
Conclusion: Over the last 12 years or so, there is increase in the number of publications on clozapine. However, there is lack of multicentric studies.
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http://dx.doi.org/10.1016/j.ajp.2022.103353 | DOI Listing |
Schizophr Res
December 2024
ClozR Registry and InSTAR Program, Schizophrenia Clinic, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
The response rate to clozapine in patients with treatment-resistant schizophrenia spectrum disorders (TRSS) is around 40 %. But, in general, a better prognosis is noted for schizophrenia in developing countries, including India. Given the scarcity of related literature from India, this study aimed to evaluate the response rates to clozapine in TRSS and explore predictors of response.
View Article and Find Full Text PDFJ ECT
October 2024
Department of Psychiatry, King George's Medical University, Lucknow, Uttar Pradesh, India
Indian J Psychol Med
January 2024
Dept. of Psychiatry, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India.
J Mov Disord
November 2024
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
J Comput Chem
January 2025
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab, India.
Cyclic nitrenium ions containing five-membered and six-membered rings are available, however, the seven-membered cyclic nitrenium ions (azepinium ions) are rare. The chemistry of these species is related to their stability originating from the aromaticity due to 6π electrons. Very few theoretical and experimental studies have been conducted on the azepinium ions.
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