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| http://dx.doi.org/10.1007/s00115-022-01413-z | DOI Listing |
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Early-onset stroke-like migraine attacks after radiation therapy syndrome: A case report and review of the literature.
J Clin Neurosci
December 2024
Departments of Neurosurgery, University of California, Los Angeles, CA, United States; Radiation Oncology, University of California, Los Angeles, CA, United States; Head and Neck Surgery, University of California, Los Angeles, CA, United States; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, United States; Los Angeles Biomedical Research Institute, University of California, Los Angeles, CA, United States; Harbor-UCLA Medical Center, University of California, Los Angeles, CA, United States; David Geffen School of Medicine, University of California, Los Angeles, CA, United States. Electronic address:
Purpose: Stroke-like migraine attacks after radiation therapy (SMART) syndrome is characterized by migraines, seizures, and stroke-like symptoms following brain irradiation. Diagnosis consists of clinical signs, history of brain irradiation, and radiographic evaluation. The latency to onset varies widely among individual patients, ranging from 1 to 35 years.
View Article and Find Full Text PDFTeaching NeuroImage: Stroke-Like Migraine Attacks After Radiation Therapy Syndrome.
Neurology
January 2025
Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada; and.
Article Synopsis
- - Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a rare complication seen in patients who have had craniospinal irradiation, typically presenting with headaches, seizures, and neurological deficits.
- - A case study of a 23-year-old with a background of childhood medulloblastoma highlights symptoms like headaches and seizures with MRI showing specific brain enhancements, but tests ruled out common causes.
- - Systemic steroid therapy significantly improved the patient's condition, emphasizing the importance of recognizing SMART syndrome to prevent unnecessary surgical procedures and ensure better patient outcomes.
Cerebral Artery Vasoconstriction After Galcanezumab Loading Dose for Migraine Prevention: A Case Report.
Pain Ther
December 2024
Los Angeles Headache Center, Los Angeles and San Diego, CA, USA.
Anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies that target CGRP ligands or receptors, may cause a very rare side effect of reversible cerebral vasoconstriction syndrome (RCVS). This study is a case report of a patient who developed cerebral artery vasoconstriction documented on serial brain magnetic resonance angiography (MRA) scans without the typical manifestations of RCVS following galcanezumab loading dose. Case report: A 40-year-old female patient with high-frequency episodic migraine with visual aura on topiramate 100 mg/day developed transient numbness of the right upper and lower extremities and right face without headache and a normal neurological examination 10 min after a loading dose of galcanezumab, which resolved over the next 2 days.
View Article and Find Full Text PDFNovel Mitochondrial Cytopathy Causing Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-Like Episodes Syndrome and Tubulointerstitial Nephropathy.
Cureus
August 2024
Internal Medicine, Stockport National Health Service (NHS) Trust, Stockport, GBR.
Article Synopsis
- Mitochondrial cytopathies, particularly from MT-TL1 and MT-ND5 mutations, can lead to mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), marked by multi-organ dysfunction, with a novel MT-ND5 variant being only the second reported case linked to MELAS.
- A middle-aged man presented with severe neurological symptoms, including confusion, speech difficulties, and behavioral changes, alongside a history of refractory seizures and renal disease; imaging revealed significant brain abnormalities, and muscle biopsy identified a novel mutation in the MT-ND5 gene.
- MELAS typically features seizures, stroke-like episodes, and other neurological issues, with kidney transplants in these patients generally offering
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