AI Article Synopsis
- The neo-Glasgow prognostic score (GPS) is a new biomarker developed to assess outcomes in hepatocellular carcinoma (HCC) patients undergoing liver surgery, and this study aimed to see if it could also predict outcomes for patients treated with atezolizumab and bevacizumab (Atez/Bev).
- An analysis of 421 HCC patients revealed that both the GPS and the neo-GPS scores were independently associated with overall survival, with higher scores indicating worse survival rates.
- The study concluded that the neo-GPS is an effective prognostic tool for evaluating advanced, unresectable HCC patients undergoing Atez/Bev treatment, offering stronger predictive power compared to the original GPS.
Article Abstract
Aim: Recently, the neo-Glasgow prognostic score (GPS), a composite biomarker determined by the C-reactive protein level and albumin-bilirubin grade, was developed to predict outcomes in hepatocellular carcinoma (HCC) patients who undergo hepatic resection. The present research investigated whether the neo-GPS could predict prognosis in HCC patients treated with atezolizumab plus bevacizumab (Atez/Bev).
Methods: A total of 421 patients with HCC who were treated with Atez/Bev were investigated.
Results: Multivariate Cox hazards analysis showed that a GPS of 1 (hazard ratio (HR), 1.711; 95% confidence interval (CI), 1.106-2.646) and a GPS of 2 (HR, 4.643; 95% CI, 2.778-7.762) were independently associated with overall survival. Conversely, multivariate Cox hazards analysis showed that a neo-GPS of 1 (HR, 3.038; 95% CI, 1.715-5.383) and a neo-GPS of 2 (HR, 5.312; 95% CI, 2.853-9.890) were also independently associated with overall survival in this cohort. Additionally, cumulative overall survival rates differed significantly by GPS and neo-GPS (p < 0.001). The neo-GPS, compared with the GPS, had a lower Akaike information criterion (1207 vs. 1,211, respectively) and a higher c-index (0.677 vs. 0.652, respectively) regarding to overall survival. In a subgroup analysis of patients considered to have a good prognosis as confirmed using a Child-Pugh score of 5 (p = 0.001), a neutrophil-to-lymphocyte ratio <3 (p = 0.001), or an α-fetoprotein level < 100 ng/mL (p < 0.001), those with a high neo-GPS (≥1) had a statistically poorer overall survival than those with a low neo-GPS.
Conclusions: The neo-GPS can predict prognosis in advanced unresectable HCC patients treated with Atez/Bev.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067064 | PMC |
| http://dx.doi.org/10.1002/cam4.5495 | DOI Listing |
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