AI Article Synopsis
- - Scleredema of Buschke is a rare connective tissue disease, categorized into three types based on underlying conditions: Type 1 (following febrile infections), Type 2 (linked to paraproteinemia), and Type 3 (scleredema diabeticorum, associated with Diabetes mellitus).
- - The disease is characterized by diffuse, non-pitting skin swelling, and skin histology shows a normal/slightly thinned epidermis with reduced elastic fibers and thick collagen bundles accompanied by mucopolysaccharide deposits.
- - A case study is presented of a 58-year-old man with scleredema diabeticorum, treated using topical steroids and improved glycemic control, along with a review of clinical and
Article Abstract
Scleredema of Buschke is a rare connective tissue disease with a poorly understood pathogenesis. Three types of scleredema have been distinguished according to its association with preceding or underlying conditions. Type 1 is usually secondary to a febrile infection, type 2 is mostly associated with paraproteinemia and type 3, usually named scleredema diabeticorum, has a strict association with Diabetes mellitus. A diffuse, non-pitting swelling and induration of the skin define this disease. The skin histology is characterized by a normal or slightly thinned epidermis, and the dermis containing a decreased number of elastic fibers and thick large swollen collagen bundles separated by mucopolysaccharide deposits in the deep reticular dermis. In this report we present a 58-year-old man with scleredema diabeticorum controlled with a topical steroid cream and an optimization of glycemic control. We reviewed clinical, histopathological characteristics and the various possible treatments.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724717 | PMC |
| http://dx.doi.org/10.4081/dr.2022.9477 | DOI Listing |
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