AI Article Synopsis
- Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that deteriorates motor neurons in the brain and spinal cord, and this study analyzed gene expression changes in postmortem samples from ALS patients and controls.
- The findings showed increased gene expression in microglia and astrocytes, while oligodendrocyte gene expression decreased, alongside the discovery of gene co-expression modules linked to disease duration.
- The study also identified potential genetic risk factors for ALS that may influence gene expression or splicing in the spinal cord, specifically highlighting the roles of certain genes like FNBP1 and ATXN3 in disease risk.
Article Abstract
Amyotrophic lateral sclerosis (ALS) is a progressively fatal neurodegenerative disease affecting motor neurons in the brain and spinal cord. In this study, we investigated gene expression changes in ALS via RNA sequencing in 380 postmortem samples from cervical, thoracic and lumbar spinal cord segments from 154 individuals with ALS and 49 control individuals. We observed an increase in microglia and astrocyte gene expression, accompanied by a decrease in oligodendrocyte gene expression. By creating a gene co-expression network in the ALS samples, we identified several activated microglia modules that negatively correlate with retrospective disease duration. We mapped molecular quantitative trait loci and found several potential ALS risk loci that may act through gene expression or splicing in the spinal cord and assign putative cell types for FNBP1, ACSL5, SH3RF1 and NFASC. Finally, we outline how common genetic variants associated with splicing of C9orf72 act as proxies for the well-known repeat expansion, and we use the same mechanism to suggest ATXN3 as a putative risk gene.
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| http://dx.doi.org/10.1038/s41593-022-01205-3 | DOI Listing |
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