Mycosynthesis of silver nanoparticles: a review.

Metallic nanoparticles currently show multiple applications in the industrial, clinical and environmental fields due to their particular physicochemical characteristics. Conventional approaches for the synthesis of silver nanoparticles (AgNPs) are based on physicochemical processes which, although they show advantages such as high productivity and good monodispersity of the nanoparticles obtained, have disadvantages such as the high energy cost of the process and the use of harmful radiation or toxic chemical reagents that can generate highly polluting residues. Given the current concern about the environment and the potential cytotoxic effects of AgNPs, once they are released into the environment, a new green chemistry approach to obtain these nanoparticles called biosynthesis has emerged. This new alternative process counteracts some limitations of conventional synthesis methods, using the metabolic capabilities of living beings to manufacture nanomaterials, which have proven to be more biocompatible than their counterparts obtained by traditional methods. Among the organisms used, fungi are outstanding and are therefore being explored as potential nanofactories in an area of research known as mycosynthesis. For all the above, this paper aims to illustrate the advances in state of the art in the mycosynthesis of AgNPs, outlining the two possible mechanisms involved in the process, as well as the AgNPs stabilizing substances produced by fungi, the variables that can affect mycosynthesis at the in vitro level, the applications of AgNPs obtained by mycosynthesis, the patents generated to date in this field, and the limitations encountered by researchers in the area.