AI Article Synopsis
- - Single-cell atlases help connect the dots between genes, diseases, and treatments by pinpointing specific cell types and their roles in disease development.
- - This understanding of disease mechanisms at the cellular level can lead to improved diagnostics, better drug targets, and new therapies, including for cancer and regenerative medicine.
- - The text outlines the transformative potential of cell atlases in medicine, highlighting advances made over the past decade in addressing various diseases like cancer, rare conditions, and even COVID-19.
Article Abstract
Single-cell atlases promise to provide a 'missing link' between genes, diseases and therapies. By identifying the specific cell types, states, programs and contexts where disease-implicated genes act, we will understand the mechanisms of disease at the cellular and tissue levels and can use this understanding to develop powerful disease diagnostics; identify promising new drug targets; predict their efficacy, toxicity and resistance mechanisms; and empower new kinds of therapies, from cancer therapies to regenerative medicine. Here, we lay out a vision for the potential of cell atlases to impact the future of medicine, and describe how advances over the past decade have begun to realize this potential in common complex diseases, infectious diseases (including COVID-19), rare diseases and cancer.
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| http://dx.doi.org/10.1038/s41591-022-02104-7 | DOI Listing |
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