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| http://dx.doi.org/10.1016/j.ejim.2022.12.001 | DOI Listing |
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Alzheimers Dement
December 2024
University of Michigan School of Public Health, Ann Arbor, MI, USA.
Background: The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic determinant for Alzheimer's disease and cognitive function in nearly all human populations, yet inconsistent effects have been reported in South Asians. The population of India has admixed genetic ancestry with most people falling on a North/South cline and having varying proportions of Ancestral North Indian (ANI) and Ancestral South Indian (ASI) ancestries, and those in east of India fall off the cline due to ancestry from additional ancestral populations. This study examined the ε4 association with cognitive function across 18 states/union territories of India and investigated whether ancestral background modulates ε4 association with cognitive function in 2,590 participants from the Longitudinal Aging Study in India - Diagnostic Assessment of Dementia (LASI-DAD).
View Article and Find Full Text PDFRole of Thyrotropin-Releasing Hormone Stimulation Test and Autoantibody in 952 Subjects with Subclinical Hypothyroidism.
J Endocr Soc
November 2024
Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul 04401, Korea.
Context: Subclinical hypothyroidism (SCH) is characterized by elevated thyroid-stimulating hormone (TSH) levels and normal free thyroxine (fT4) levels. In upper normal TSH levels, thyrotropin-releasing hormone (TRH) stimulation test proved to be useful in identifying an exaggerated TSH response.
Objective: We aimed to evaluate the incidence and predictive ability of basal TSH, anti-thyroid peroxidase antibodies (TPOAb), and anti-thyroglobulin antibodies (TgAb) for exaggerated TRH stimulation test in SCH.
Comparing newly developed SNP barcode panels with microsatellites to explore population genetics of malaria parasites in the Peruvian Amazon.
Front Genet
December 2024
Instituto de Medicina Tropical "Alexander von Humboldt", Universidad Peruana Cayetano Heredia, Lima, Peru.
Introduction: Malaria molecular surveillance (MMS) can provide insights into transmission dynamics, guiding national control programs. We previously designed AmpliSeq assays for MMS, which include different traits of interest (resistance markers and deletions), and SNP barcodes to provide population genetics estimates of and parasites in the Peruvian Amazon. The present study compares the genetic resolution of the barcodes in the AmpliSeq assays with widely used microsatellite (MS) panels to investigate population genetics of Amazonian malaria parasites.
View Article and Find Full Text PDFBackground: The emergence of the COVID-19 pandemic led to increased levels of depression among adolescents in 2019. However, the situation regarding adolescent depression in the later stages of the pandemic remains unclear. This study investigated depressive symptoms status and changing trends among middle and junior high school students from 2019 to 2023.
View Article and Find Full Text PDFEstimating undiagnosed dementia in England using capture recapture techniques.
BMC Geriatr
January 2025
University of Southampton, Southampton, UK.
Background: To our knowledge capture-recapture techniques have not been used to estimate dementia prevalence using routinely collected data in England, nor have they been used to estimate changes in undiagnosed dementia over time. In this study we aimed to use routinely collected electronic health records to estimate the number of undiagnosed dementia cases there are in England and how this has changed over time. We also aimed to assess whether proportion of undiagnosed cases differed by age group, ethnicity, socioeconomic deprivation and sex.
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