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Stoichiometry of the Heteromeric Nicotinic Receptors of the Renshaw Cell.
J Neurosci
May 2018
Centre National de la Recherche Scientifique Unité Mixte de Recherche 8118, Université Paris Descartes, Paris, France.
Neuronal nicotinic acetylcholine receptors (nAChRs) are pentamers built from a variety of subunits. Some are homomeric assemblies of α subunits, others heteromeric assemblies of α and β subunits which can adopt two stoichiometries (2α:3β or 3α:2β). There is evidence for the presence of heteromeric nAChRs with the two stoichiometries in the CNS, but it has not yet been possible to identify them at a given synapse.
View Article and Find Full Text PDFSegregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse.
Sci Rep
June 2017
Physiologie cérébrale, CNRS UMR 8118, Université Paris Descartes, Paris, France.
In neonatal mice motoneurons excite Renshaw cells by releasing both acetylcholine (ACh) and glutamate. These two neurotransmitters activate two types of nicotinic receptors (nAChRs) (the homomeric α receptors and the heteromeric α*ß* receptors) as well as the two types of glutamate receptors (GluRs) (AMPARs and NMDARs). Using paired recordings, we confirm that a single motoneuron can release both transmitters on a single post-synaptic Renshaw cell.
View Article and Find Full Text PDFHigh affinity and low affinity heteromeric nicotinic acetylcholine receptors at central synapses.
J Physiol
October 2014
Laboratory of Cerebral Physiology, CNRS UMR 8118, Université Paris Descartes 45 rue des Saints Pères, Paris, 75006, France.
Most neuronal heteromeric nicotinic receptors seem able to adopt two different stochiometries depending on the ratio of α and β subunits. In recombinant receptors these two stoichiometries have been associated with different affinities to ACh, but it is not known which stoichiometry is present at nicotinic synapses in the nervous system. One possible clue to this identification is the speed of decay of the synaptic currents.
View Article and Find Full Text PDFSubunit composition and kinetics of the Renshaw cell heteromeric nicotinic receptors.
Biochem Pharmacol
October 2013
Neurophysique et Physiologie, CNRS UMR 8119, Université Paris Descartes, France.
In Renshaw cells (RCs) of newborn mice, activation of motoneurons elicits a four-component synaptic current (EPSC) mediated by two glutamate receptors and two nicotinic receptors (nAChRs). We have analyzed the nicotinic component of the EPSC which is blocked by dihydro-beta-erythroidine (DHβE) with the dual objective of identifying the nAChR subunits involved and of understanding the kinetics of the response. The sensitivity to DHβE of the peak of the EPSC was differentially affected by genetic deletion of three specific nAChR subunits: α2, β2 and β4.
View Article and Find Full Text PDFBrain plasticity: Paradoxical case of a neurodegenerative disease?
Curr Biol
October 2012
FAPSE, University of Geneva, 40 bd du Pont d'Arve, CH-1205, Geneva, Switzerland.
A thought-provoking new study has found that symptom-free carriers of the neurodegenerative Huntington's disease present a dramatic two-fold acceleration in perceptual learning.
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