MTCC 1750 enhances oxidative stress resistance and lifespan extension with improved physiological and functional capacity in via the DAF-16 pathway.

Redox imbalance plays a crucial role in the development of age-related diseases, and resistance to oxidative stress is crucial for optimum longevity and healthy aging. Using the wild-type, mutant and transgenic strains, this study explored the antioxidative potential and lifespan extension benefits of different in (). We observed that MTCC 1750 could enhance the resistance of against juglone induced oxidative stress by reducing its intracellular reactive oxygen species (ROS) accumulation. Also, live MTCC 1750 could prolong the worm's lifespan. These effects are dependent on transcription factor DAF-16 evident with significant upregulation of its target gene . This also explained the significant improvements in different age-associated changes in physiological and mechanical parameters of the worm by MTCC 1750. Further investigations revealed that DAF-16 activation and, its enhanced translocation in the nucleus is independent of DAF-2 or JNK pathway. These findings highlighted MTCC 1750 as a potent anti-oxidant source for complementing current antioxidant therapeutic strategies. Nonetheless, the findings showed how different signaling events are regulated based on an organism's diet component, and their consequences on the aging process in multiple species.