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Anticipation augments distal leg muscle neuromechanics before, during, and after treadmill-induced perturbations applied during walking.
J Biomech
January 2025
Joint Department of Biomedical Engineering, University of North Carolina Chapel Hill and North Carolina State University, 116 Manning Drive, Chapel Hill, NC 27599, USA. Electronic address:
We investigated the effect of anticipation on the proactive and reactive neuromechanical responses of the distal leg muscles in 20 young adults to anticipated and unanticipated rapid anterior or posterior treadmill-induced balance perturbations applied during walking. We quantified local medial gastrocnemius (MG) and tibialis anterior (TA) neuromechanics using cine B-mode ultrasound and surface electromyography before, during, and after the perturbation. Our findings partially supported the hypothesis that anticipated perturbations would elicit greater proactive agonist muscle adjustments than unanticipated perturbations.
View Article and Find Full Text PDFA Nomogram Built on Clinical Factors and CT Attenuation Scores for Predicting Treatment Response of Acute Myeloid Leukemia Patients.
Biomedicines
January 2025
Clinical Research Center, Jiangnan University Medical Center, 68 Zhongshan Road, Wuxi 214002, China.
Acute myeloid leukemia (AML) is an aggressive cancer with variable treatment responses. While clinical factors such as age and genetic mutations contribute to prognosis, recent studies suggest that CT attenuation scores may also predict treatment outcomes. This study aims to develop a nomogram combining clinical and CT-based factors to predict treatment response and guide personalized therapy for AML patients.
View Article and Find Full Text PDFRole of digital technology in epidemic control: a scoping review on COVID-19 and Ebola.
BMJ Open
January 2025
Department of Midwifery, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan Aman, Ethiopia.
Objective: To synthesise the role of digital technologies in epidemic control and prevention, focussing on Ebola and COVID-19.
Design: A scoping review.
Data Sources: A systematic search was done on PubMed, HINARI, Web of Science, Google Scholar and a direct Google search until 10 September 2024.
Sialidase fusion protein protects against influenza infection in a cigarette smoke-induced model of COPD.
Mucosal Immunol
January 2025
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Biology of Inflammation Center, Baylor College of Medicine, Houston, TX 77030, USA; Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey, Houston, TX 77030, USA. Electronic address:
First- and secondhand smokers are at an increased risk for influenza virus (IFV)-related respiratory failure and death. Despite approved influenza antiviral treatments, there is an unmet need for treatments that can improve outcomes in populations at risk for respiratory failure, including tobacco users with Chronic Obstructive Pulmonary Disease (COPD). Here we show that the sialidase fusion protein, DAS181, reduced viral burden, mitigated inflammation, and attenuated lung function loss, consistent with broad-spectrum anti-influenza responses in a mouse model of COPD and IFV-A infection.
View Article and Find Full Text PDFA Review of Clonal Relationships in Myeloproliferative Neoplasms With Co-Mutations of JAK2, CALR or MPL and BCR::ABL1.
Clin Lymphoma Myeloma Leuk
December 2024
Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
BCR::ABL1-negative myelo-proliferative neoplasms (MPNs) are characterized by mutations in JAK2, CALR, or MPL. Usually these mutations are co-exclusive of each other and of BCR::ABL1. We reviewed clonal interactions in 177 subjects with mutations in JAK2, CALR, or MPL and BCR::ABL1 including JAK2/BCR::ABL1 (N = 142), CALR/BCR::ABL1 (N = 31), MPL/BCR::ABL1 (N = 3).
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