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| http://dx.doi.org/10.1002/ctm2.1115 | DOI Listing |
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The impact of POSTN on tumor cell behavior and the tumor microenvironment in lung adenocarcinoma.
Int Immunopharmacol
January 2025
Department of Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital Affiliated to Shandong First Medical University, Shandong Academy of Medical Science, Jinan, Shandong, China; Department of Radiation Oncology, Shandong University Cancer Center, Jinan, Shandong, China. Electronic address:
Background: The role of cancer-associated fibroblasts (CAFs) in modulating the anti-tumor immune response in lung adenocarcinoma (LUAD) remains elusive, primarily due to the heterogeneous nature of these cells. This heterogeneity muddles the understanding of their impact on immunotherapy effectiveness.
Methods: We utilized the LUAD single-cell dataset to precisely classify tumor cells and CAFs.
Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis.
Am J Respir Cell Mol Biol
December 2024
Boston University School of Medicine, Boston, Massachusetts, United States;
Idiopathic pulmonary fibrosis (IPF) is characterized by the sustained activation of interstitial fibroblasts leading to excessive collagen deposition and progressive organ failure. Epigenetic and metabolic abnormalities have been shown to contribute to the persistent activated state of scar-forming fibroblasts. However, how epigenetic changes regulate fibroblast metabolic responses to promote fibroblast activation and progressive fibrosis remains largely unknown.
View Article and Find Full Text PDFComprehensive RNA Sequencing Analysis Identifies Network Hub Genes and Biomarkers Differentiating Desmoid-type Fibromatosis From Reactive Fibrosis.
Lab Invest
November 2024
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:
Article Synopsis
- Desmoid-type fibromatosis (DTF) is a benign but aggressive tumor caused by persistent activation of fibroblasts, differing from transient activation seen in reactive fibrosis (RF).
- A comparative analysis of gene expression in DTF and RF tissues revealed over 4,200 genes uniquely expressed in DTF, linked to development and muscle function, while RF genes pertained to immune responses.
- Key transcription factors associated with DTF were identified, and specific genes showed potential as biomarkers, with TWIST2 outperforming β-catenin as a diagnostic indicator for DTF.
Altered AP-1, RUNX and EGR chromatin dynamics drive fibrotic lung disease.
bioRxiv
October 2024
Division of Rheumatology and Clinical Immunology, University of Pittsburgh.
Pulmonary fibrosis, including systemic sclerosis-associated interstitial lung disease (SSc-ILD), involves myofibroblasts and SPP1 macrophages as drivers of fibrosis. Single-cell RNA sequencing has delineated fibroblast and macrophages transcriptomes, but limited insight into transcriptional control of profibrotic gene programs. To address this challenge, we analyzed multiomic snATAC/snRNA-seq on explanted SSc-ILD and donor control lungs.
View Article and Find Full Text PDFEvidence for a lipofibroblast-to- + myofibroblast reversible switch during the development and resolution of lung fibrosis in young mice.
Eur Respir J
November 2024
The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, China.
Article Synopsis
- Fibrosis, especially idiopathic pulmonary fibrosis (IPF), is linked to abnormal healing processes in the lungs that can lead to organ failure, with no current cure.
- The study investigates activated myofibroblasts (aMYFs), their different subtypes, and their roles in lung repair and damage using genetic and transcriptomic analysis in mice, as well as human data.
- Findings reveal that aMYFs can be categorized into four distinct groups, with a specific subset linked to both the progression and resolution of fibrosis, suggesting new potential treatment targets for managing IPF.
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