AI Article Synopsis
- The study analyzed polymorphisms in the HLA gene across 11 loci in 4,845 Chinese Han individuals using next-generation sequencing techniques.
- It identified a total of 44 DPB1, 13 DPA1, 20 DQA1, and 19 DRB3/4/5 alleles, revealing significant differences in allelic variations between the Chinese population and established CWD data from the US and Europe.
- The findings contribute to the revision of HLA-CWD allele lists, aiding in improvements to the IMGT/HLA database and enhancing understanding of hematopoietic stem cell and organ transplantation.
Article Abstract
The focus of this study was to analyze polymorphisms in the HLA gene at 11 loci in 4845 Chinese Han populations using next-generation sequencing methods, and to compare common and well-documented (CWD) allelic differences between China and other CWD lists. A total of 44 DPB1 alleles, 13 DPA1 alleles, 20 DQA1 alleles and 19 DRB3/4/5 alleles were detected in this study. About 20%-50% of the CWD alleles in China differ from the American Society for Histocompatibility and Immunogenetics and European Federation for Immunogenetics (EFI) data. The revised list of HLA-CWD alleles in the Han population will provide additional data for the update of the IMGT/HLA database and contribute to a better understanding of hematopoietic stem cell transplantation and organ transplantation.
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| http://dx.doi.org/10.1111/tan.14932 | DOI Listing |
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