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Omentum preservation versus complete omentectomy in gastrectomy for gastric cancer (OMEGA trial): study protocol for a randomized controlled trial.
Trials
September 2024
Amsterdam UMC Location, Department of Surgery, Amsterdam, the Netherlands.
Background: Potentially curative therapy for locally advanced gastric cancer consists of gastrectomy, usually in combination with perioperative chemotherapy. An oncological resection includes a radical (R0) gastrectomy and modified D2 lymphadenectomy; generally, a total omentectomy is also performed, to ensure the removal of possible microscopic disease. However, the omentum functions as a regulator of regional immune responses to prevent infections and prevents adhesions which could lead to bowel obstructions.
View Article and Find Full Text PDFOmental metastases in patients with pseudomyxoma peritonei or colorectal peritoneal metastases - is routine omentectomy justified?
Int J Hyperthermia
June 2024
Department of Surgical Sciences, Colorectal Surgery, Uppsala University, Uppsala, Sweden.
Background: The greater omentum is routinely resected during cytoreductive surgery (CRS), but few studies have analyzed the rationale behind this. This study aimed to assess the prevalence of omental metastases (OM) and the correlation between macroscopically suspected and microscopically confirmed OM, in patients with pseudomyxoma peritonei (PMP) or colorectal peritoneal metastases (PM).
Method: All patients without previous omentectomy, treated with initial CRS and hyperthermic intraperitoneal chemotherapy for PMP or colorectal PM, at Uppsala University Hospital in 2013-2021, were included.
Metastasis of colorectal cancer to the uterine body and fallopian tube: case report and literature review.
J Surg Case Rep
June 2024
Department of Oncology, Radiotherapy and Reconstructive Surgery, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119435, Russia.
Article Synopsis
- - This case study highlights a rare instance of colorectal cancer spreading to the fallopian tube and uterus in a 61-year-old woman, who initially underwent surgery for stage pT3N0M0 colorectal cancer.
- - After a six-month follow-up without issues, she experienced a recurrence and started chemoradiotherapy, leading to a full response.
- - Eventually, pelvic pain led to imaging that revealed a mass in her fallopian tube and uterus, resulting in surgery that confirmed the metastasis of her rectal cancer.
Introduction: Continuous ambulatory peritoneal dialysis is an important modality of renal replacement therapy in children. Catheter dysfunction (commonly obstruction) is a major cause of morbidity and is a significant concern that hampers renal replacement therapy. As omentum is a significant cause of obstruction, some recommend routine omentectomy during insertion of the peritoneal dialysis catheter.
View Article and Find Full Text PDFPatient-Derived Exosomes as siRNA Carriers in Ovarian Cancer Treatment.
Cancers (Basel)
April 2024
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
RNA interference is a powerful gene-silencing tool with potential clinical applications. However, its therapeutic use is challenging because suitable carriers are unavailable. Exosomes are stable small endogenous vesicles that can transport functional molecules to target cells, making them ideal small interfering RNA (siRNA) carriers.
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