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http://dx.doi.org/10.3389/fpsyt.2022.1074120 | DOI Listing |
Front Immunol
December 2024
Periodontology Unit, UCL Eastman Dental Institute, University College London, London, United Kingdom.
Periodontitis is a highly prevalent chronic disease. Despite decades of extensive research on the topic, a complete understanding of its immunopathogenesis, especially when linked to other inflammatory comorbidities, is lacking. human and animal experiments have shown the host inflammatory response's crucial role in both the disease's onset and its systemic implications.
View Article and Find Full Text PDFFront Health Serv
December 2024
School of Social Work, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Background: Professionals who provide implementation support in human service systems describe relationships as being critical to support evidence use; however, developing trusting relationships are not strongly featured in implementation science literature. The aims of this study were to (a) assess the feasibility and acceptability of a theory-driven training and coaching approach for building trusting relationships among members of an implementation team who were supporting the implementation of an evidence-informed program in a public child welfare system in the United States and (b) gauge the initial efficacy of the approach in terms of the development of trusting relationships and subsequent implementation outcomes.
Methods: Consistent with a convergent mixed-methods approach, we collected both quantitative and qualitative data to address our research questions.
Cancer Lett
December 2024
Digestive Diseases Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, 518107, China. Electronic address:
Cancer associated fibroblasts (CAFs) are the predominant stromal cells in the tumor microenvironment of gastric cancer (GC), interacting with both immune and tumor cells to drive cancer progression. However, the precise link between these interactions and their potential as therapeutic targets remains poorly understood. In this study, we identified for the first time that nicotinamide N-methyltransferase (NNMT) derived from CAFs promoted M2 macrophage polarization, which, in turn, facilitated the proliferation and migration of GC cells.
View Article and Find Full Text PDFPhenomics
October 2024
Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012 Shandong China.
Unlabelled: Recently, there has been a debate regarding the association between polycystic ovary syndrome (PCOS) and pancreatic cancer (PC). In order to examine the causal relationship between PCOS and PC, we conducted a Mendelian randomization study, which utilized 12 single nucleotide polymorphisms (SNPs) identified from a genome-wide association study (GWAS) meta-analysis that included 10,074 PCOS cases and 103,164 controls of European ancestry as instrumental variables (IVs). The outcome data were obtained from the FinnGen database (including 605 cases and 218,187 controls).
View Article and Find Full Text PDFWorld J Pediatr
December 2024
University of Illinois-Chicago, Chicago, Illinois, USA.
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