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Assessment of dynamic cerebral autoregulation in near-infrared spectroscopy using short channels: A feasibility study in acute ischemic stroke patients. | LitMetric

AI Article Synopsis

  • The study investigates how cerebral autoregulation (CA) can be assessed in acute ischemic stroke (AIS) patients using near-infrared spectroscopy (NIRS), aiming to improve early detection of CA deterioration.
  • Researchers monitored changes in blood pressure and brain blood flow in 27 AIS patients and 27 healthy controls by altering head positions and using different NIRS channels.
  • Results showed that AIS patients had significantly lower gain in low-frequency oscillations of blood pressure compared to controls, suggesting impaired CA, but further research is necessary to confirm these findings.

Article Abstract

Introduction: In acute ischemic stroke, progressive impairment of cerebral autoregulation (CA) is frequent and associated with unfavorable outcomes. Easy assessment of cerebral blood flow and CA in stroke units bedside tools like near-infrared spectroscopy (NIRS) might improve early detection of CA deterioration. This study aimed to assess dynamic CA with multichannel CW-NIRS in acute ischemic stroke (AIS) patients compared to agematched healthy controls.

Methods: CA reaction was amplified by changes in head of bed position. Long- and short channels were used to monitor systemic artery pressure- and intracranial oscillations simultaneously. Gain and phase shift in spontaneous low- and very low-frequency oscillations (LFO, VLFO) of blood pressure were assessed.

Results: A total of 54 participants, 27 with AIS and 27 age-matched controls were included. Gain was significantly lower in the AIS group in the LFO range (i) when the upper body was steadily elevated to 30. and (ii) after its abrupt elevation to 30°. No other differences were found between groups.

Discussion: This study demonstrates the feasibility of NIRS short channels to measure CA in AIS patients in one single instrument. A lower gain in AIS might indicate decreased CA activity in this pilot study, but further studies investigating the role of NIRS short channels in AIS are needed.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719939PMC
http://dx.doi.org/10.3389/fneur.2022.1028864DOI Listing

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