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Ion Pair Chromatography for Endogenous Metabolite LC-MS Analysis in Tissue Samples Following HGH Resolution Untargeted Acquisition.
Methods Mol Biol
January 2025
Bioscience, Research and Early Development, Oncology, AstraZeneca, Cambridge, Cambridgeshire, UK.
A protocol for the preparation of tissue extracts for the targeted analysis ca. 150 polar metabolites, including those involved in central carbon metabolism, is described, using a reversed phase ion pair U(H)PLC-MS method. Data collection enabled in high-resolution mass spectrometry detection provides highly specific and sensitive acquisition of metabolic intermediates with wide range physicochemical properties and pathway coverage.
View Article and Find Full Text PDFAdvances, Challenges, and Opportunities in Plasmonic Nanogap-Enhanced Raman Scattering with Nanoparticles.
ACS Nano
January 2025
Department of Chemistry, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, South Korea.
Surface-enhanced Raman scattering has been widely used for molecular/material characterization and chemical and biological sensing and imaging applications. In particular, plasmonic nanogap-enhanced Raman scattering (NERS) is based on the highly localized electric field formed within the nanogap between closely spaced metallic surfaces to more strongly amplify Raman signals than the cases with molecules on metal surfaces. Nanoparticle-based NERS offers extraordinarily strong Raman signals and a plethora of opportunities in sensing, imaging and many different types of biomedical applications.
View Article and Find Full Text PDF[Teaching Concept Hanover : Digitally integrated teaching for medical students at the University Clinic for Ophthalmology of the Hanover Medical School].
Ophthalmologie
January 2025
Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
Background: Challenges in practice-oriented teaching at university clinics are increasing. A lack of resources contrasts a growing number of students. Digital lectures, seminars, and blended-learning concepts enable resource-efficient and effective teaching in ophthalmology.
View Article and Find Full Text PDFSKP1-CUL1-F-box: Key molecular targets affecting disease progression.
FASEB J
January 2025
Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
The correct synthesis and degradation of proteins are vital for numerous biological processes in the human body, with protein degradation primarily facilitated by the ubiquitin-proteasome system. The SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase, a member of the Cullin-RING E3 ubiquitin ligase (CRL) family, plays a crucial role in mediating protein ubiquitination and subsequent 26S proteasome degradation during normal cellular metabolism. Notably, SCF is intricately linked to the pathogenesis of various diseases, including malignant tumors.
View Article and Find Full Text PDFLongitudinal Associations Between Neighborhood Environments and Functional Disabilities among Community-Dwelling Older Adults in China.
J Gerontol B Psychol Sci Soc Sci
January 2025
Department of urban and rural planning, Shenzhen International School of Design, Harbin Institute of Technology. Shenzhen, China.
Objectives: This study aims to investigate the longitudinal associations between neighborhood environments and functional disabilities over time among older adults in China. Urban-rural disparities in these associations were examined in this study.
Methods: Data from four waves of the China Health and Retirement Longitudinal Study (2011-2018) were analyzed, including a sample of 5,379 older adults aged 60 and over.
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