dNTP concentrations do not increase in mammalian cells in response to DNA damage.

Cell Metab

Department of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden. Electronic address:

Published: December 2022

A recent publication reported a uniform ∼5- to 6-fold increase in dNTP pools 30 min after exposure to ionizing radiation. Das et al. were not able to reproduce these results. Their data instead agree with earlier publications reporting no increase in dNTP pools in mammalian cells in response to DNA damage.

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Source
http://dx.doi.org/10.1016/j.cmet.2022.11.002DOI Listing

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