[Clinical Study on the Distribution Frequency of Anti-Mur in Southern Fujian Area and Its Cause of Hemolytic Disease of the Newborn].

Objective: To investigate the distribution frequency of anti-Mur and the characteristics of hemolytic disease of the newborn by anti-Mur in this region, and to provide basis for guiding clinical safe blood transfusion.

Methods: Anti-Mur detected in blood preparation or transfusion cases from November 2020 to December 2021 in our hospital were retrospectively analyzed, the laboratory test data and relevant clinical data of the patients were statistically analyzed.

Results: Among 39 069 cases of blood preparation or transfusion, 345 cases of irregular antibody were detected, including 23 cases of anti-Mur, 7 cases of male, and 4 cases of blood transfusion history. Among the 16 women, 9 had history of only pregnancy, 2 had history of only blood transfusion, and 5 had history of both blood transfusion and pregnancy. The median age of anti-Mur patients was 59(19-78) years old, which was higher than the median age of other positive patients in the same period, 45(1 day-93 year) years old (<0.05), but there was no significant difference in gender between groups (＞0.05). A child with hyperbilirubinemia was diagnosed with hemolytic disease of the newborn by anti-Mur after detection of anti-Mur in erythrocyte elution liquid and maternal serum.

Conclusion: Anti-Mur has important clinical significance in Southern Fujian area, and its generation is closely related to the history of immunization. The age of anti-Mur detected is higher than that of other positive patients. Hemolytic disease of the newborn caused by anti-Mur has severe anemia symptoms and is easy to miss detection, which should be paid more attention to.