AI Article Synopsis
- The study aimed to analyze the presence of fusion genes in children with acute lymphoblastic leukemia (ALL) and their impact on prognosis based on different immunophenotypes.
- Among the 86 children analyzed, B cell type was predominant, but T cell type showed higher fusion gene detection rates.
- Findings indicated that certain fusion genes and presence of minimal residual disease are linked to worse outcomes, establishing them as risk factors for poor prognosis in ALL patients.
Article Abstract
Objective: To observe the detection of fusion gene in children with acute lymphoblastic leukemia (ALL) of different immunophenotypes, and analyze the relationship between fusion gene and prognosis.
Methods: The clinical data of 86 children with ALL treated in the hospital from May 2015 to May 2020 were retrospectively analyzed, the immunophenotypes and the prognosis of children were recorded, the detection of fusion gene in ALL children with different immunophenotypes was compared, the relationship between detection of fusion gene and prognosis was analyzed.
Results: The results of bone marrow immunophenotype showed that there were 13 cases of T cell type and 73 cases of B cell type in 86 children with ALL. The detection rate of fusion gene in ALL children with T cell type was significantly higher than that in ALL children with B cell type (0.05). The detection rates of fusion genes , and in ALL children with B cell type were higher than those in ALL children with T cell type, but the differences were not statistically significant (>0.05). Followed up for 8-12 months, recurrence was taken as the end point, the average follow-up time was (10.14±1.75) months, in 86 children with ALL 15 cases recurred (17.44%). The recurrence curve drawn by Kaplan-Meier method showed that the median recurrence time of 15 children with recurrent ALL was 9 months. The proportions of positive minimal residual disease and extramedullary infiltration in the poor prognosis group were higher than those in the good prognosis group, and the differences were statistically significant (0.05). The detection rates of fusion genes and in the poor prognosis group were higher than those in the good prognosis group, and the differences were statistically significant (all 0.05). Logistic regression analysis showed that positive minimal residual lesions, extramedullary infiltration, and detection of fusion genes and were risk factors for poor prognosis in children with ALL (>1, 0.05). The ROC curve analysis showed that the area under the curve (AUC) of combined detection of fusion gene and for predicting the poor prognosis of ALL children was >0.707, which had a certain predictive value.
Conclusion: There are differences in fusion genes among ALL children with different immunophenotypes, minimal residual disease, extramedullary infiltration, and fusion gene are associated with prognosis of ALL children. Fusion gene detection can be used as new method to predict the prognosis of children with ALL.
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| http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2022.06.008 | DOI Listing |
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