AI Article Synopsis
- Five new diterpenes, named sinudenoids A-E, were discovered in a type of soft coral.
- Sinudenoid A has a unique 5/5/11 fused tricyclic structure, while sinudenoids B-D have a common tetracyclic structure but differ in their frameworks.
- Sinudenoid E features a rare 8/8 bicyclic carbon structure and shows notable anti-inflammatory effects in a zebrafish model.
Article Abstract
Five new furanobutenolide-derived C-norcembranoid diterpenes, sinudenoids A-E (, respectively), were isolated from the soft coral . Sinudenoid A () possesses an uncommon 5/5/11-fused tricyclic ring system. Sinudenoids B-D (, respectively) share the same tetracyclic 5/5/6/6 ring system but represent two kinds of new skeletons. Sinudenoid E () is the second compound with the rare 8/8 bicyclic carbon core. A plausible biosynthesis pathway for compounds is proposed. Compound exhibits strong anti-inflammatory activity in the zebrafish model.
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| http://dx.doi.org/10.1021/acs.orglett.2c03631 | DOI Listing |
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