Instrumented impact testing allows the applicability of conventional Charpy tests to be extended toward assessing mechanical properties such as dynamic fracture toughness and dynamic tensile properties. In this work, we present design considerations for engineering instrumented strikers for Charpy V-notch impact testing. Specific attention is given to the mechanical and geometric features, as well as the placement of strain gauges and corresponding bridge circuits for instrumentation. These design considerations are intended to make the sensitivity invariant to the location and distribution of impact forces. The concepts presented in this work were applied to an actual instrumented striker, which was then statically calibrated. Data from this calibration indicate that the device has good repeatability, shows a linear response, and is relatively insensitive to impact location.
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http://dx.doi.org/10.6028/jres.125.010 | DOI Listing |
JAMA Health Forum
January 2025
School of Medicine, Graduate School of Business, Stanford University, Stanford, California.
Importance: Few studies have examined the extent to which employers emphasize financial over nonfinancial criteria in measurement, reporting, and decision-making about health care benefits.
Objective: To measure and identify factors associated with financial over nonfinancial emphasis in employer decision-making about health benefits.
Design, Setting, And Participants: A survey was administered to a nationally representative sample of US employers to assess the extent of employers' emphasis on benefits plans' costs over member experience, access to care, and equity, and on financial vs other considerations when choosing third-party benefits administrators.
JAMA Netw Open
January 2025
Faculty of Medicine, Sana'a University, Sana'a, Yemen.
Importance: Rapid digitalization of health care and a dearth of digital health education for medical students and junior physicians worldwide means there is an imperative for more training in this dynamic and evolving field.
Objective: To develop an evidence-informed, consensus-guided, adaptable digital health competencies framework for the design and development of digital health curricula in medical institutions globally.
Evidence Review: A core group was assembled to oversee the development of the Digital Health Competencies in Medical Education (DECODE) framework.
J Chem Inf Model
January 2025
Zhejiang Laboratory, Hangzhou 311100, Zhejiang, China.
Deoxyribonucleic acid (DNA) serves as a repository of genetic information in cells and is a critical molecular target for various antibiotics and anticancer drugs. A profound understanding of small molecule interaction with DNA is crucial for the rational design of DNA-targeted therapies. While the molecular mechanics/Poisson-Boltzmann surface area (MM/PBSA) and molecular mechanics/generalized Born surface area (MM/GBSA) approaches have been well established for predicting protein-ligand binding, their application to DNA-ligand interactions has been less explored.
View Article and Find Full Text PDFJ Esthet Restor Dent
January 2025
Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Objective: To test the clinical application of LCM-printed lithium disilicate veneers.
Clinical Considerations: A female patient with tooth wear was scanned with intraoral scanner (Prime Scan, Dentsply Sirona). The six non-prep veneers were designed (DentalCAD, Exocad) and printed from lithium disilicate with an LCM-printer with the thickness of 0.
Blue emitters are crucial in the organic light emitting diode (OLED) industry and scientific field. In this work, we prepared a novel donor-π-acceptor (D-π-A) molecular PCZ-P-PY using pyrene as a bridge to construct hybrid local and charge-transfer (HLCT) state with weak charge-transfer (CT) property. This excited state design give rise to the high photoluminescent quantum yield (PLQY), more importantly, it is also responsible for the high exciton utilization efficiency (EUE) by constructing efficient hot-exciton channel.
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