commonly known as in Thai, a traditional medicinal herb, is being developed for clinical use in cholangiocarcinoma. β-eudesmol and atractylodin are the main active components of this herb which possess most of the pharmacological properties. However, the lack of adequate toxicity data would be a significant hindrance to their further development. The present study investigated the toxic effects of selected concentrations of β-eudesmol and atractylodin in the heart, liver, and endocrine systems of zebrafish embryos. Study endpoints included changes in the expression of genes related to activity in the heart, fatty acid-binding protein 10a and cytochrome P450 family 1 subfamily A member 1 in the liver, and cortisol levels in the endocrine system. Both compounds produced inhibitory effects on the gene expressions in the heart. Both also triggered the biomarkers of liver toxicity. While β-eudesmol did not alter the expression of gene, atractylodin at high concentrations upregulated the gene, suggesting its potential enzyme-inducing activity in this gene. β-eudesmol, but not atractylodin, showed some stress-reducing properties with suppression of cortisol production.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306152 | PMC |
| http://dx.doi.org/10.1177/00368504221137458 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Atractylodin mitigates UVB radiation-induced oxidative stress and photoaging responses by enhancing NrF2 signaling in human epidermal keratinocytes.
Arch Dermatol Res
December 2024
Department of Dermatology, Jinshan Hospital of Fudan University, Shanghai, 201508, China.
This study explores the protective role of Atractylodin (ATN) on ultraviolet-B (UVB) radiation-exposed oxidative damage and photoaging responses in human epidermal keratinocytes (HaCaT). In vitro, experiments involved subjecting HaCaT cells to UVB radiation (50 mJ/cm) for a 24 h incubation period, leading to cell death, increased reactive oxygen species (ROS), and DNA damaged lesion (8-Oxo Gunosine). ATN treatment effectively mitigated cell toxicity, ROS generation, and 8-Oxo Gunosine in UVB-exposed HaCaT cells.
View Article and Find Full Text PDFAtractylodin alleviates polycystic ovary syndrome by inhibiting granule cells ferroptosis through pyruvate dehydrogenase kinase 4-mediated JAK-STAT3 pathway.
Int Immunopharmacol
December 2024
Departments of Gynaecology and Obstetrics, The Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China. Electronic address:
Article Synopsis
- Polycystic ovary syndrome (PCOS) is commonly associated with oxidative stress, and this study explores the potential of atractylodin (ATR) to alleviate PCOS symptoms through its antioxidant properties.
- A mouse model of PCOS was established to assess how ATR affects hormone levels, estrous cycles, and ovarian morphology, with in vitro experiments further investigating ATR's impact on cell viability and oxidative stress markers.
- The findings suggest that ATR significantly improves hormone levels and ovarian structure by regulating the expression of PDK4 and inhibiting cell death, indicating ATR's potential as a therapeutic option for PCOS treatment.
[Tissue distribution of volatile compounds in secretory cavities of different rhizome sections of wild Atractylodes lancea and A. lancea transplanted for different years].
Zhongguo Zhong Yao Za Zhi
October 2024
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University Guangzhou 510006, China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China Key Laboratory of Biology and Cultivation of Herb Medicine, Ministry of Agriculture and Rural Affairs Beijing 100700, China.
Laser capture microdissection(LCM) combined with gas chromatography-mass spectrometry(GC-MS) was employed to investigate the distribution of volatile compound in the secretory cavities of different tissues(cortex, phloem, xylem, and pith) in different rhizome sections of wild Atractylodes lancea. The same method was used to study the metabolic characteristics of the volatile compounds in the secretory cavities of different rhizome tissues of A. lancea transplanted for 1-3 years.
View Article and Find Full Text PDFand Its Constituent, Atractylodin, Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK Activation.
Biomol Ther (Seoul)
November 2024
Department of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.
Article Synopsis
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is a serious health issue linked to insulin resistance, involving conditions from simple fat accumulation in the liver to liver cancer.
- A study explored the effects of a traditional herbal remedy used in East Asia and its active ingredient, atractylodin, on treating MASLD in mice, showing reductions in body weight, liver fat, and blood sugar levels after 8 weeks on a high-fat diet.
- The findings revealed that atractylodin activated a key protein (AMPK), leading to improvements in obesity, fatty liver, and glucose metabolism, indicating its potential as a treatment option for MASLD.
Atractylodin modulates ASAH3L to improve galactose metabolism and inflammation to alleviate acute lung injury.
iScience
October 2024
College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China.
Acute lung injury (ALI) is a lung disease characterized by an excessive inflammatory response and damage to lung epithelial cells. Atractylodin (ATL) has good anti-inflammatory activity and protects the integrity of the epithelial cell barrier. However, the efficacy of ATL in the treatment of ALI and its mechanism is unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!