AI Article Synopsis
- The study examines the impact of different human milk supplementation methods on cognitive and motor development in preterm infants.
- It compares two groups: one receiving individualized and optimized nutrition, and another receiving only optimized nutrition, using the Bayley Scales of Infant and Toddler Development.
- Results showed no significant differences in development scores between the two groups after 18-38 months, indicating the type of supplementation did not affect outcomes.
Article Abstract
Background: Human milk supplementation for preterm infants in the neonatal intensive care unit (NICU) can be based on optimized nutrition (feeding adjustments based on growth and measurements of serum nutrients) or individualized nutrition (measurements of macronutrients in mother's own milk).
Objective: To compare Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) at 18-38mo adjusted age in infants who had been randomly allocated to individualized+optimized nutrition (experimental group) vs optimized nutrition alone (control) in the NICU.
Methods: Double-blinded randomized controlled trial in neonates <29wks gestational age (GA) and those <34wks GA and small for GA.
Results: Bayley scores were assessed in 91/114 (80%) infants. The two study groups had similar frequencies of low cognitive, motor and language Bayley scores and similar age-adjusted Bayley scores in bivariate and multivariate analyses.
Conclusions: The type of human milk supplementation provided had no significant effect on Bayley scores assessed at 18-38mo.
Trial Registration: This randomized controlled trial was registered at ClinicalTrials.gov NCT02372136.
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| http://dx.doi.org/10.1038/s41372-022-01572-6 | DOI Listing |
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