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Functional Regrowth of Norepinephrine Axons in the Adult Mouse Brain Following Injury.
eNeuro
January 2025
Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
It is widely believed that axons in the central nervous system of adult mammals do not regrow following injury. This failure is thought, at least in part, to underlie the limited recovery of function following injury to the brain or spinal cord. Some studies of fixed tissue have suggested that, counter to dogma, norepinephrine (NE) axons regrow following brain injury.
View Article and Find Full Text PDFChild Neurology: Neurophysiologic and Anatomical Correlates in Startle Epilepsy: A Comprehensive SEEG Investigation for Successful Resective Surgery.
Neurology
January 2025
From the Department of Neurological Surgery (J.K., S.H.H.), Asan Medical Center; and Department of Pediatrics (M.-J.K., M.-S.Y., T.-S.K.), Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea.
Startle epilepsy, characterized by startle-provoked epileptic seizures, was historically recognized as one of the reflex epilepsies but currently lacks classification as a specific epileptic syndrome because of insufficient characterization. This study presents an institutional experience and review of relevant literature focusing on the neurophysiologic and anatomical aspects of startle epilepsy. We describe a pediatric patient with an underlying structural etiology of left frontal encephalomalacia who continued to experience disabling seizures despite multiple antiseizure medications and previous palliative surgery.
View Article and Find Full Text PDFAtomic Force Microsocopy: Key Unconventional Approach for Bacterial Nanotubes Characterization In Vivo.
ACS Omega
November 2024
Laboratoire de Physique des Solides (LPS), UMR CNRS 8502, University Paris-Saclay, University Paris-Sud, Orsay 91405, France.
Article Synopsis
- Bacterial communication plays a critical role in controlling growth and addressing issues like antimicrobial resistance and energy production in Microbial Fuel Cells.
- Recent findings have identified a novel type of communication between bacteria using nanotubes, which are tiny filaments enabling direct nutrient exchange between neighboring cells.
- This study utilizes atomic force microscopy (AFM) in liquid to provide the first direct visualization of bacterial nanotubes on live bacteria, shedding light on their properties and potential applications in managing bacterial behavior.
Relationship between reticulospinal system sensitization and proprioceptive pathways in the development of dynamic spasticity (ReProDS) post-spinal cord injury: protocol for a prospective, observational cohort study.
BMC Neurol
November 2024
Department of Neurology and Neurological Rehabilitation, Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 201619, China.
Background: Dynamic spasticity (DS) is a common complication post-spinal cord injury (SCI), marked by intermittent increases in muscle tone during postural transitions or movement. Despite its prevalence, high-quality research on DS incidence, risk factors, and underlying mechanisms in SCI patients remains limited. With the growing application of spinal cord stimulation (SCS) for spasticity control, the role of proprioception in DS development has garnered attention.
View Article and Find Full Text PDFDefects in Exosome Biogenesis Are Associated with Sensorimotor Defects in Zebrafish Mutants.
J Neurosci
December 2024
Department of Otolaryngology, Stanford University, Stanford, California
Mutations in human are associated with neurodevelopmental defects, including motor delays and defective muscle tone. encodes a AAA-ATPase required for membrane scission, but how mutations in lead to impaired control of motor function is not known. Here we identified a mutation in zebrafish , T248I, that affects sensorimotor transformation.
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