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Comparison of repeated toxicity of polyhexamethyleneguanidine phosphate, a causative agent of humidifier disinfectant tragedy, in young and adult mice.
Sci Rep
October 2024
Center for Large Animals Convergence Research, Korea Institute of Toxicology, Jeongeup, 56212, Republic of Korea.
Article Synopsis
- Some drugs, like PHMG-P, can have different toxicity effects in infants compared to adults, raising concerns from a past incident in 2011.
- A study compared the toxicity of PHMG-P in young (7-10 days old) and adult (8 weeks old) mice, using controlled doses and assessing various health impacts after multiple exposures.
- Both age groups showed significant lung toxicity and inflammation, but adult mice experienced noticeable weight loss, highlighting the need for further research on the long-term effects of early-life exposure to PHMG-P.
Neonatal Tetanus Case Series: A Tale of Survival and Tragedy at St Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Pediatric Health Med Ther
July 2024
Ohio State Global One Health LLC, Addis Ababa, Ethiopia.
Background: Neonatal tetanus remains a significant threat in regions with limited healthcare access, despite being preventable through vaccination. The case-fatality rate of untreated neonatal tetanus is close to 100%. Even one case of neonatal tetanus regarded as a failure of the healthcare system, making it essential to remain mindful of this disease's relevance to public health.
View Article and Find Full Text PDFNational chlorhexidine coverage and factors associated with newborn umbilical cord care in Bangladesh and Nepal: a cross-sectional analysis using household data.
Matern Health Neonatol Perinatol
June 2024
School of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden.
Background: Preventable newborn deaths are a global tragedy with many of these deaths concentrated in the first week and day of life. A simple low-cost intervention, chlorhexidine cleansing of the umbilical cord, can prevent deaths from omphalitis, an infection of the umbilical cord. Bangladesh and Nepal have national policies promoting chlorhexidine use, as well as routinely collected household survey data, which allows for an assessment of coverage and predictors of the intervention.
View Article and Find Full Text PDFDeterminants of stillbirth among women who delivered in hospitals of North Wollo Zone, Northeast Ethiopia: A case-control study.
PLoS One
April 2024
School of Nursing, College of Health Sciences, Woldia University, Woldia, Ethiopia.
Background: Stillbirth is a silent tragedy that shatters the lives of women, families, and nations. Though affecting over 2 million infants globally in 2019, it remains overlooked, with no specific targets dedicated to its reduction in the sustainable development goals. Insufficient knowledge regarding the primary risk factors contributing to stillbirths hinders efforts to reduce its occurrence.
View Article and Find Full Text PDFState of South Dakota's Child: 2022.
S D Med
January 2023
University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
In 2021, South Dakota observed an increase in the number of births from 2020 when the state experienced its lowest historic birth rate. Nonetheless, this increase represented a 3.7 percent decrease from the state's previous five year (2016-2020) mean of live births.
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