AI Article Synopsis
Article Abstract
Unlabelled: We registered 1336 incident-validated fractures in a prospective cohort of 3560 postmenopausal (60-85 years) Belgian women (mean follow-up of 9.1 years). The increase of fracture incidence with age varied widely depending on the fracture site and was significantly steeper for central than for peripheral fractures (e.g., not significant for the ankle).
Introduction: The epidemiology of fracture sites other than MOFs has been less studied. We examined the incidence of fractures according to their sites in a prospective cohort of postmenopausal Belgian women.
Methods: Three thousand five hundred sixty postmenopausal women, aged 60-85 years old, were recruited from 2007 to 2013 and surveyed yearly (FRISBEE). The number of validated incident fractures was recorded and analyzed in relation to age and the fracture site.
Results: One thousand three hundred thirty-six fractures were recorded after a mean follow-up of 9.1 years. Seven hundred fifty-six fractures (57%) were MOFs and 580 (43%) non-MOFs, while 813 (61%) were central and 523 (39%) peripheral. The increase of fracture incidence with age differed between fracture sites and was steeper for central than for peripheral fractures. The ratio of MOFs to non-MOFs increased significantly with age, from 1.10 (95% CI: 0.83-1.45) for the 60-69 to 1.69 [1.42-2.01] for the 80-89-year subgroup (P = 0.017). This was also true for central versus peripheral fracture. We differentiated three groups of fracture incidence evolution with age: fractures with a mean increase/decade (compared to the 60-69 age group) of less than 1.5, 1.5-2.0, and 2.0-3.0. The lowest increase was seen for most peripheral fractures, whereas the greatest increase included hip, scapula, pelvis, ribs, and spine fractures.
Conclusion: The increase of fracture incidence with age varied widely depending on the fracture site, and the ratio of MOFs to non-MOFs rose significantly with age. Some peripheral fractures, such as the ankle, did not increase significantly with age, suggesting that bone fragility does not play a major role in their occurrence.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11657-022-01191-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of Percutaneous Kyphoplasty and Percutaneous Pedicle Screw Fixation in Managing Osteoporotic Vertebral Compression Fractures in Middle-Aged and Elderly Individuals: A Comparative Study.
Ann Ital Chir
December 2024
Department of Orthopedics, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, 215000 Suzhou, Jiangsu, China.
Aim: This study is aims to compare the clinical efficacy and safety of percutaneous kyphoplasty (PKP) and percutaneous pedicle screw fixation (PPSF) in managing osteoporotic vertebral compression fractures (OVCFs) among middle-aged and elderly individuals.
Methods: A total of 142 patients aged 55-65 years were selected retrospectively from the Department of Orthopedics of our hospital from June 2021 to June 2023 and classified into PKP (n = 68) and PPSF (n = 74) groups. General data of patients were collected, and related perioperative indicators, Visual Analog Scale (VAS) scores, Oswestry Disability Index (ODI), Activities of Daily Living (ADL) scores, changes in Cobb angle of the fractured vertebrae, vertebral compression rate, as well as postoperative complications were compared between the two groups.
Injuries to the lower limbs and associated injuries in children and adolescents resulting from road traffic incidents.
J Family Med Prim Care
November 2024
2nd Department of Surgery-Pediatric Surgery and Orthopedics, "Grigore T. Popa" University of Medicine and Pharmacy Iaşi, Iaşi, Romania.
Background: Fractures occurring in the lower extremities as a result of road traffic accidents (RTAs) can lead to considerable morbidity and constitute a large proportion of nonfatal injuries that necessitate hospitalization. The present study aimed to examine the epidemiology of lower extremity fractures linked with RTAs in pediatric patients.
Methods: This is a descriptive retrospective research study carried out between 2015 and 2022 at St.
Relationship between cardiorespiratory fitness and falls in older adults: A population-based study.
Geriatr Gerontol Int
December 2024
Laboratory of Social Dimensions Applied to Physical Activity and Sport (LABSAFE), Department of Physical Education and Sports, Rural Federal University of Rio de Janeiro, Seropédica, Brazil.
Aim: The present study investigated the relationship between cardiorespiratory fitness (CRF) and episodes and severity of falls in older adults.
Methods: This cross-sectional study drew on data from the Brazilian 2019 National Health Survey. The sample consisted of 18 991 older adults (aged ≥60 years).
CCL2/CCR2 Signalling in Mesenchymal Stem/Progenitor Cell Recruitment and Fracture Healing in Mice.
J Cell Mol Med
December 2024
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Macrophage efferocytosis (clearance of apoptotic cells) is crucial for tissue homeostasis and wound repair, where macrophages secrete factors that promote resolution of inflammation and regenerative signalling. This study examined the role of efferocytic macrophage-associated CCL2 secretion, its influence on mesenchymal stem/progenitor cell (MSPC) chemotaxis, and in vivo cell recruitment using Ccr2 (KO) mice with disrupted CCL2 receptor signalling in two regenerative models: ossicle implants and ulnar stress fractures. Single cell RNA sequencing and PCR validation indicated that efferocytosis of various apoptotic cells at bone injury sites (osteoblasts, pre-osteoblasts, MSPC) upregulated CCL2.
View Article and Find Full Text PDFEffect of Time to Surgery on Surgical Site Infection in Open Distal Radius Fractures: A Review of the ACS Trauma Quality Improvement Program Database.
Hand (N Y)
December 2024
NYU Langone Health, New York, USA.
Introduction: Managing open distal radius fractures (DRFs) poses challenges. While preventing surgical site infection (SSI) involves prompt antibiotic administration and thorough irrigation and debridement, the impact of urgent intervention on reducing postoperative infection rates is debated. We hypothesize that timing of surgery does not significantly affect the incidence of SSI in open DRF treated within or after 24 hours from time of injury.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!