AI Article Synopsis
- Direct amination of C-H or C=C bonds with unprotected amino groups is difficult, particularly using common metal ions.
- A bioinspired iron(II) complex can successfully catalyze the double amination using hydroxylamine derivatives as amine donors.
- Changing the benzyl branch to a methyl group enables the aziridination reaction of styrene.
Article Abstract
Direct amination of C-H or CC bonds using unprotected amino groups is very challenging, especially with earth abundant metal ions. Here we show that a bioinspired iron(II) complex catalyses the double amination of its dangling benzyl branch in the presence of hydroxylamine derivatives as the unprotected amine donor and that the replacement of the benzyl branch by a methyl group also allows the aziridination of styrene.
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| http://dx.doi.org/10.1039/d2cc04992a | DOI Listing |
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