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An AI-based imaging flow cytometry approach to study erythrophagocytosis.
Cytometry A
October 2024
Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, Amsterdam, The Netherlands.
Erythrophagocytosis is a process consisting of recognition, engulfment and digestion by phagocytes of antibody-coated or damaged erythrocytes. Understanding the dynamics that are behind erythrophagocytosis is fundamental to comprehend this cellular process under specific circumstances. Several techniques have been used to study phagocytosis.
View Article and Find Full Text PDFKikuchi-Fujimoto disease, a rare benign disease with atypical histomorphology: more than meets the eye.
Pathology
April 2024
Department of Pathology, PSG Institute of Medical Sciences and Research, Coimbatore, India. Electronic address:
Kikuchi-Fujimoto disease (KFD) is a benign self-limiting condition primarily affecting young females. It usually presents with fever and cervical lymphadenopathy of unknown aetiology with a preponderance of the Asian population. Histopathology is critical in making an accurate diagnosis.
View Article and Find Full Text PDFNeutrophil-like pH-responsive pro-efferocytic nanoparticles improve neurological recovery by promoting erythrophagocytosis after intracerebral hemorrhage.
Theranostics
January 2024
Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310016, China.
Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disease resulting from blood extravasating into the brain parenchyma. Escalation of erythrophagocytosis (a form of efferocytosis), avoiding the consequent release of the detrimental erythrocyte lysates, may be a promising target of ICH management. The ADAM17 inhibitor and liver X receptor (LXR) agonist could promote efficient efferocytosis and injury repair.
View Article and Find Full Text PDFMetabolization of Resolvin E4 by ω-Oxidation in Human Neutrophils: Synthesis and Biological Evaluation of 20-Hydroxy-Resolvin E4 (20-OH-RvE4).
ACS Pharmacol Transl Sci
December 2023
Department of Pharmacy, Section for Pharmaceutical Chemistry, University of Oslo, P.O. Box 1068, 0316 Oslo, Norway.
Resolvin E4 (RvE4) belongs to the resolvin family of specialized pro-resolving mediators (SPMs). The resolvins are endogenously formed mediators with both potent pro-resolving and anti-inflammatory biological activities and have attracted considerable attention in both inflammation research and drug discovery. Hence, further metabolism of the resolvins is of interest.
View Article and Find Full Text PDFErythrophagocytosis by dysplastic neutrophils and their precursors.
Int J Lab Hematol
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Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
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