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| http://dx.doi.org/10.1002/jha2.530 | DOI Listing |
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Central nervous system crystal-storing histiocytosis: A case report and literature review.
Eur J Neurol
January 2025
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Article Synopsis
- Crystal-storing histiocytosis (CSH) is a rare condition where abnormal protein crystals accumulate in the body, and when it affects the CNS, it can cause persistent imaging abnormalities.* -
- The study describes one local case of CNS CSH alongside 10 other cases, noting that 9 had brain parenchyma involvement and some cases were linked to conditions like lymphoma.* -
- While CNS CSH is uncommon, comprehensive evaluation for related malignancies is crucial, and treatment focuses on addressing these underlying conditions.*
Gaucher-like crystal-storing histiocytosis associated with kappa chain myeloma: A case report with next generation sequencing study.
Pathol Res Pract
November 2024
Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:
Article Synopsis
- * The case study illustrates a patient with kappa chain myeloma who exhibited Gaucher-like crystal-storing histiocytosis in bone marrow, identified through various methods including biopsy and next generation sequencing (NGS).
- * Findings indicated the presence of distinct rhomboid crystals and several genetic mutations linked to poorer survival rates in myeloma patients, suggesting that pathologists should consider crystal-storing histiocytosis when identifying such crystals in bone marrow.
Background: Crystalloid storage histiocytosis (CSH) is a rare clinical condition characterized by abnormally high numbers of histiocytes with a large accumulation of crystalline immunoglobulins. Due to its relative rarity, clinical diagnosis of it is frequently incomplete or incorrect. We report a case with pulmonary crystal-storing histiocytosis that was mistakenly identified as lung carcinoma.
View Article and Find Full Text PDFCutaneous crystal storing histiocytosis: A case series with review of literature.
J Cutan Pathol
July 2024
Department of Pathology, Cleveland Clinic, Ohio, USA.
Crystal-storing histiocytosis (CSH) is a rare condition in which crystals accumulate in the cytoplasm of histiocytes and is usually associated with a lymphoplasmacytic neoplasm. Cutaneous CSH is extraordinarily rare and limited to case reports in the literature. We report two cases of this disease with cutaneous involvement.
View Article and Find Full Text PDFThe Matter of Kidney Biopsy in Monoclonal Gammopathy of Renal Significance: A Case Report of a New Pattern of Immunoglobulin-Storing Histiocytosis.
Case Rep Nephrol Dial
December 2023
Division of Nephrology Dialysis and Transplantation, Renal Transplantation Center, "A. Vercellone," Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, Italy.
Monoclonal gammopathy of renal significance (MGRS) represents a group of disorders, characterized by paraproteinemia which causes renal damage. These disorders never meet the diagnostic criteria for multiple myeloma (MM) or lymphoproliferative disease. Crystal-storing histiocytosis is one of the rarest patterns of MGRS, characterized by an accumulation of light chains of crystals within histiocyte's cytoplasm, located in bone marrow or other extramedullary sites such as the kidney, cornea, or thyme.
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