Severe burn is a serious acute trauma that can lead to significant complications such as sepsis, multiple organ failure, and high mortality worldwide. The gut microbiome, the largest microbial reservoir in the human body, plays a significant role in this pathogenic process. Intestinal dysbiosis and disruption of the intestinal mucosal barrier are common after severe burn, leading to bacterial translocation to the bloodstream and other organs of the body, which is associated with many subsequent severe complications. The progression of some intestinal diseases can be improved by modulating the composition of gut microbiota and the levels of its metabolites, which also provides a promising direction for post-burn treatment. In this article, we summarised the studies describing changes in the gut microbiome after severe burn, as well as changes in the function of the intestinal mucosal barrier. Additionally, we presented the potential and challenges of microbial therapy, which may provide microbial therapy strategies for severe burn.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714625 | PMC |
| http://dx.doi.org/10.3389/fcimb.2022.974259 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of Clinical Outcomes and Quality of Life following the Karydakis Flap Procedure for Pilonidal Sinus Treatment.
Adv Skin Wound Care
January 2025
At the Department of Plastic, Reconstructive and Hand Surgery, Center for Severe Burn Injuries, Paracelsus Medical University, Klinikum Nürnberg, Germany, David Breidung, MD, is Resident, and Moritz Billner, MD, is Attending Physician. Philipp Buben, MD, is Resident, Department for Plastic and Reconstructive Surgery, Burn Unit, BG Kliniken Bergmannstrost, Germany. Gerrit Grieb, MD, PhD, is Head of Department, Department of Plastic Surgery and Hand Surgery, Gemeinschaftskrankenhaus Havelhoehe, Germany. Also in the Department of Plastic, Reconstructive and Hand Surgery, Center for Severe Burn Injuries, Paracelsus Medical University, Klinikum Nürnberg, Reiner Sievers, MD, is Attending Physician; Bert Reichert, MD, is Professor and Head of Department; Ioannis-Fivos Megas, MD, is past Chief Resident; and André A. Barth, MD, is Chief Resident.
Objective: To evaluate the clinical outcome of the Karydakis flap procedure performed by a single surgeon for the treatment of pilonidal sinus, focusing on postoperative complications, recurrence rate, wound healing time, and return to daily life.
Methods: Authors performed a retrospective data analysis of patients who underwent reconstruction of pilonidal sinus using the Karydakis technique at the Department of Plastic, Reconstructive and Hand Surgery, Center for Severe Burn Injuries of Paracelsus Medical University, Klinikum Nürnberg, Germany, between 2014 and 2021. All cases were performed by a single surgeon.
Country economic status is strongly associated with burn survival - validation of the (modified) ABSI.
Int J Equity Health
January 2025
Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
Background: Predicting burn-related mortality is vital for family counseling, triage, and resource allocation. Several of the burn-specific mortality prediction scores have been developed, including the Abbreviated Burn Severity Index (ABSI) in 1982. However, these scores are not tested for accuracy to support contemporary estimates of the global burden of burn injury.
View Article and Find Full Text PDFEffectiveness of a comic book intervention on mental health literacy among adolescents and youth in Burkina Faso: a randomized controlled trial protocol.
BMC Public Health
January 2025
Department of Psychiatry and Psychotherapy (Campus Charité Mitte), Charité - Universitätsmedizin Berlin, Berlin, Germany.
Background: In Burkina Faso, nearly half of the population is under 15 years old, and one in four adolescents experience depression. This underscores the critical need to enhance mental health literacy among adolescents and youth, empowering them to manage their mental well-being effectively. Comic books offer an engaging approach to health education, yet their effectiveness in addressing mental health remains largely untested.
View Article and Find Full Text PDFMultidisciplinary integration and fusion based on critical care medicine and immunology: History, current status, and prospects.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
August 2024
Third Xiangya Hospital, Central South University, Changsha 410013.
Critical care medicine focuses on understanding the pathophysiological mechanisms and treatment approaches for life-threatening conditions, including sepsis, severe trauma/burns, hemorrhagic shock, heatstroke, and acute pancreatitis, all of which have high incidence rates. These conditions are primarily characterized by acute multi-organ dysfunction, with sudden onset, severe illness, and high mortality rates. Additionally, critical care treatment demands substantial medical resources, imposing significant economic burdens on patients' families and society.
View Article and Find Full Text PDFIncreased prehospital mortality in patients with combined burns and trauma in Canada: Analysis of a provincial trauma registry database.
Burns
December 2024
Trauma Nova Scotia, Nova Scotia Health, Halifax, NS B3H 2Y9, Canada. Electronic address:
Introduction: The combination of burns and non-thermal trauma may have a synergistic effect on mortality. Our objective was to determine if burn patients with concomitant trauma are at increased risk of mortality in both the prehospital and in-hospital settings.
Methods: Data were collected from a population-based provincial trauma registry (2001-2019).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!