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Severe Late-Onset Drug-Induced Immune Thrombocytopenia Following IFN -1a Treatment: A Case Report of a 52-Year-Old Woman with Relapse-Remitting Multiple Sclerosis. | LitMetric

Severe Late-Onset Drug-Induced Immune Thrombocytopenia Following IFN -1a Treatment: A Case Report of a 52-Year-Old Woman with Relapse-Remitting Multiple Sclerosis.

Case Rep Hematol

Service and Central Laboratory of Hematology, Department of Oncology and Department, Laboratories and Pathology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland.

Published: November 2022

AI Article Synopsis

Article Abstract

Interferon -1a (IFN1a) is considered safe in relapsing-remitting multiple sclerosis (RRMS). Drug-induced thrombocytopenia (DITP) is a rare but underreported adverse event that is often confused with other causes of thrombocytopenia. We report the case of a 52-year-old woman who developed limb and oral mucosa petechiae and hematochezia, 10 years after beginning IFN1a. Blood work showed an isolated severe thrombocytopenia and ruled out other autoimmune diseases, viral infections, intravascular hemolysis, and renal impairment. Oral corticosteroids and tranexamic acid were initiated with a favorable platelet response. IFN1a was resumed, leading to recurrence of thrombocytopenia. Platelets came back to normal after intravenous immunoglobulins and IFN1a was definitively discontinued. To our knowledge, this is the first case of drug-induced immune thrombocytopenia (DITP) associated with IFN1a.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715335PMC
http://dx.doi.org/10.1155/2022/2767031DOI Listing

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