AI Article Synopsis
- Researchers studied liver graft macrosteatosis in over 26,000 transplant donors to redefine acceptable steatosis levels, categorizing them into high-risk (≥20%) and low-risk (<20%).
- Results showed that low-risk steatotic grafts had significantly better graft survival rates (93.3% at 90 days) compared to high-risk groups, which led to worse outcomes as steatosis levels increased.
- The findings propose a new classification system for liver grafts based on steatosis percentage, which can help assess risk and improve transplant outcomes.
Article Abstract
Background: Graft macrosteatosis can predispose to a higher risk of graft loss so we sought to redefine acceptable cutoffs for graft steatosis.
Methods: Data of 26,103 donors who underwent liver transplantation (LT) between January 2004 and December 2018 from the UNOS-STAR database were utilized. A high-risk steatotic (HRS) graft and a low-risk steatotic (LRS) graft were defined as ≥20% and <20% macrosteatosis, respectively. High-risk steatotic grafts were further classified as grafts with 20-29% (G1S grafts), 30-39% (G2S grafts), and ≥40% steatosis (G3S grafts). Outcomes between groups were compared.
Results: LRS grafts had excellent graft (93.3 and 87.7%) and overall survival (95.4 and 90.5%) at 90 days and 1 year. Compared to LRS grafts, G1S, G2S, and G3S grafts had worse graft and overall survival at 90 days and 1-year ( <0.001). There was no difference in graft or overall survival of G1S or G3S grafts compared to G2S grafts until after adjustment in which G3S grafts were found to be associated with an increased risk of graft loss-aHR 1.27 (1.03-1.57), = 0.02.
Discussion: Liver grafts can be categorized into three categories: (1) <20% or "very low risk", (2) 20-39% or "low-to-moderate risk", and usually acceptable, and (3) ≥40% steatosis or "moderate-to-high risk".
How To Cite This Article: Da BL, Satiya J, Heda RP, . Outcomes after Liver Transplantation with Steatotic Grafts: Redefining Acceptable Cutoffs for Steatotic Grafts. Euroasian J Hepato-Gastroenterol 2022;12(Suppl 1):S5-S14.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681573 | PMC |
| http://dx.doi.org/10.5005/jp-journals-10018-1361 | DOI Listing |
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