Background: Malaria parasites cause a tremendous burden of disease in both the tropics and subtropics areas. Growing of drugs resistance in parasites is one of the most threats to malaria control. The aim of study was to investigate the anti-malarial activity of nano-emodin isolated from on in mice to evaluate parasites inhibition rate using test.
Methods: The study was conducted in the School of Public Health, Tehran University of Medical Sciences, during 2020. Nano-emodin particles were prepared from and confirmed by Zeta Potential Analyzer, DLS and electron microscopy techniques. Mice were infected with and treated by emodin nano-particles. Parasitemia was evaluated in each group in comparison with control group. Toxicity test was done using twice the highest concentration of emodin extract on a separate group of mice and ED50 was calculated.
Results: Emodin extract was significantly effective in all concentrations on D4 <0.05). The most effective on parasitemia was observed in 400 mg/kg of Liquid Nano-emodin and solid (non-Nano) emodin. ED50 for emodin extract was determined 220 mg/kg. Toxicity test showed no toxic effect on the subjects.
Conclusion: The emodin extract is safe, lack of side effects. So, it can be used for more and longer period of time and in higher doses. Emodin extract, either in form of liquid and nanoparticle or in a solid form, has the same therapeutic effect on in infected Balb/c mice.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682369 | PMC |
| http://dx.doi.org/10.18502/ijpa.v17i3.10624 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Insecticidal and Bactericidal Activities of Vahl and Molecular Docking Analysis of Insect Acetylcholinesterase.
Turk J Pharm Sci
January 2025
University of Tlemcen, Faculty of Science, Department of Chemistry, Laboratory of Natural and Bioactive Substances, Tlemcen, Algeria.
Objectives: This study focused on the phytochemical, insecticidal, and bactericidal activities of Vahl, as well as molecular docking analysis of an acetylcholinesterase (AChE) inhibitor as a promising natural insecticide.
Materials And Methods: The leaves of were successively extracted with n-hexane, acetone, and methanol. Silica gel column chromatography of the methanol extract yielded compound 1.
Potential Effects of Bioactive Compounds of Plant-Based Foods and Medicinal Plants in Chronic Kidney Disease and Dialysis: A Systematic Review.
Nutrients
December 2024
Department of Pharmaceutical & Health Sciences, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Madrid, Spain.
Background: The bioactive components of plant foods and medicinal plants have attracted interest due to their potential impact on the progression of chronic kidney disease (CKD) and outcomes.
Objective: This study aimed to conduct a critical and quantitative systematic review of randomized clinical trials (RCTs) investigating the potential effects of selected phytochemicals from plant-based foods and medicinal plants in CKD and dialysis patients.
Methods: The review included studies that related plant-based bioactive compounds (curcumin, propolis, sulforaphane, betalain, catechins, rhein, emodin, aloe-emodin, flavonoids, and triptolide) and medicinal plants (green tea, rhubarb, , and Hook F) in CKD and dialysis patients.
Revolutionising shift in advanced wound healing therapies: nanoengineered herbal gels.
Nat Prod Res
December 2024
Shri Guru Ram Rai University, Dehradun, India.
Recent advancements in nanogel formulations have significantly enhanced the therapeutic efficacy of herbal medicines in wound healing applications. This systematic review explores the integration of various herbal extracts and bioactive compounds into nano gels, highlighting their improved properties and wound healing application. Key formulations include tobacco stem nanogels demonstrating stability and rapid wound contraction, neem and silk fibroin hydrogels accelerating wound regeneration, and curcumin nanosuspension-based nanogels significantly enhancing wound contraction rates.
View Article and Find Full Text PDFIntegrated systems pharmacology, molecular docking, and MD simulations investigation elucidating the therapeutic mechanisms of BHD in Alzheimer's disease treatment.
Metab Brain Dis
November 2024
Department of Biotechnology, National Institute of Technology, Andhra Pradesh, 534101, India.
Alzheimer's disease (AD) poses a longstanding health challenge, prompting a century-long exploration into its etiology and progression. Despite significant advancements in medical science, current AD treatments provide only symptomatic relief, urging a shift towards innovative paradigms. This study, departing from the amyloid hypothesis, integrates Systems Pharmacology, Molecular Docking and Molecular Dynamic Simulations to investigate a polyherbal phytoformulation (US 7,273,626 B2) rooted in Ayurveda for AD, consisting of Bacopa monnieri, Hippophae rhamnoides, and Dioscorea bulbifera (BHD).
View Article and Find Full Text PDFBiological Potential of Extracts: α-Glucosidase and Antibiofilm Activities In Vitro.
Molecules
October 2024
Gastroenterology Unit, Department of Medical Science and Public Health, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
Type 2 diabetes (T2D), characterized by insulin resistance and β-cell dysfunction, requires continuous advancements in management strategies, particularly in controlling postprandial hyperglycemia to prevent complications. Current antidiabetics, which have α-amylase and α-glucosidase inhibitory activities, have side effects, prompting the search for better alternatives. In addition, diabetes patients are particularly vulnerable to yeast infections because an unusual sugar concentration promotes the growth of spp.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!