Relationship between obstructive sleep apnea-hypopnea syndrome and osteoporosis adults: A systematic review and meta-analysis.

Chaoyu Wang Zhiping Zhang Zhenzhen Zheng Xiaojuan Chen Yu Zhang Chunhe Li Huimin Chen Huizhao Liao Jinru Zhu Junyan Lin Hongwei Liang Qiuying Yu Riken Chen Jinhua Liang

Front Endocrinol (Lausanne)

Department of Endocrinology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.

Published: December 2022

This study examines how obstructive sleep apnea-hypopnea syndrome (OSAHS) is linked to osteoporosis, focusing on its effects on the incidence of the disease and bone mineral density (BMD) in the lumbar spine.
A systematic search of multiple databases identified 15 articles involving over 113,000 subjects, revealing that people with OSAHS have a significantly higher incidence of osteoporosis and lower lumbar spine BMD and T-scores compared to a control group.
The study concludes that increased awareness and management of OSAHS is essential to lower the risk of osteoporosis, emphasizing the need for active sleep intervention strategies.

Objective: This study is undertaken to explore the relationship between obstructive sleep apnea-hypopnea syndrome (OSAHS) and osteoporosis, including the relationship between OSAHS and osteoporosis incidence, lumbar spine bone mineral density (BMD), and lumbar spine T-score.

Method: Cochrane Library, PubMed, Embase, Web of Science, and other databases are searched from their establishment to April 2022. Literature published in 4 databases on the correlation between OSAHS and osteoporosis,lumbar spine BMD,lumbar spine T-score is collected. Review Manager 5.4 software is used for meta-analysis.

Results: A total of 15 articles are selected, including 113082 subjects. Compared with the control group, the OSAHS group has a higher incidence of osteoporosis (OR = 2.03, 95% CI: 1.26~3.27, Z = 2.90, P = 0.004), the lumbar spine BMD is significantly lower (MD = -0.05, 95% CI: -0.08~-0.02, Z = 3.07, P = 0.002), and the lumbar spine T-score is significantly decreased (MD = -0.47, 95% CI: -0.79~-0.14, Z = 2.83, P = 0. 005).

Conclusion: Compared with the control group, the OSAHS group has a higher incidence of osteoporosis and decreased lumbar spine BMD and T-score. In order to reduce the risk of osteoporosis, attention should be paid to the treatment and management of adult OSAHS, and active sleep intervention should be carried out.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712780	PMC
http://dx.doi.org/10.3389/fendo.2022.1013771	DOI Listing

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