Introduction Menopause is an important period in a woman's life. It is the permanent cessation of menses for 12 months or more. Menopause can develop over a long period of time. The average age for menopause to start is 52 years, but it can begin at any time from age 40 to 58 years. Many symptoms are related to postmenopausal syndrome: hot flashes, irritability, mood swings, insomnia, dry vagina, difficulty concentrating, mental confusion, stress incontinence, urge incontinence, osteoporotic symptoms, depression, headache, and vasomotor symptoms. Quality of life (QOL) has been defined by the World Health Organization (WHO) as an "individual's perceptions of their position in life in the context of the cultural and value systems in which they live and in relation to their goals, expectations, standards, and concerns." Methods A cross-sectional study was conducted among participants from Aseer's Healthy Cities. The sample was calculated using the formula of Swinscow and Cohen, and a total of 823 main cities were the target sample size. The sample was simply picked at random from October to December 2021. The Menopause Rating Scale (MRS)-related questionnaire is used to evaluate the symptoms of menopause in people who answer the questions themselves. Result The study included 869 participants, 98.3% of which are Saudi nationals. Of the participants, 82.1% were married. As regards the lifestyle of the participants in the study, 69% live with a husband and children. The mean age of the study participants was 42.5 (standard deviation (SD): 8.883) years. The mean number of participants with somatic vasomotor symptoms was 0.74 (SD: 94). The majority of the participants have sleep issues such as difficulty falling asleep, difficulty sleeping through the night, and waking up early (mean: 0.97, SD: 1.3), followed by hot flashes and sweating (mean: 0.65, SD: 1.165), and heart discomfort (mean: 0.63, SD: 12). Psychosocial symptoms are also common (mean: 0.95, SD: 1.16); the majority have depressive moods (mean: 1.09, SD: 1.35), followed by irritability (mean: 0.93, SD: 1.2), and anxiety (mean: 0.84, SD: 1.22). Physical symptoms are also prevalent, with a mean and SD of 0.91 and 1.03, respectively, with bladder problems having a mean and SD of 0.55 and 1.017, respectively. Finally, there were also sexual symptoms (mean: 0.70, SD: 1.09), with sexual problems having a mean and SD of 0.81 and 1.28, respectively. Conclusion The study found a high percentage of unawareness about menopause and a need to improve healthcare access and symptomatic treatment. The regression model of psychosocial risk factors is found to have a significant association with the increase of symptoms and using other medications for any reason, menstrual cycle pattern, and marital status.
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http://dx.doi.org/10.7759/cureus.31942 | DOI Listing |
ACS Sens
January 2025
Sensor Engineering Department, Faculty of Science and Engineering, Maastricht University, P.O. Box 616, 6200 MDMaastricht, The Netherlands.
Malaria is a major public healthcare concern worldwide, representing a leading cause of death in specific regions. The gold standard for diagnosis is microscopic analysis, but this requires a laboratory setting, trained staff, and infrastructure and is therefore typically slow and dependent on the experience of the technician. This study introduces, for the first time, a biomimetic sensing platform for the direct detection of the disease.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Porous silicon (pSi) has gained substantial attention as a versatile material for various biomedical applications due to its unique structural and functional properties. Initially used as a semiconductor material, pSi has transitioned into a bioactive platform, enabling its use in drug delivery systems, biosensing, tissue engineering scaffolds, and implantable devices. This review explores recent advancements in macrostructural pSi, emphasizing its biocompatibility, biodegradability, high surface area, and tunable properties.
View Article and Find Full Text PDFACS Chem Neurosci
January 2025
School of Medicine, Shanghai University, Shanghai 200444, China.
Noninvasive imaging of β-amyloid is pivotal for the early diagnosis of Alzheimer's disease (AD). While single imaging methods have been extensively studied for detecting Aβ over the past decade, dual-modal probes have received scant attention. In this study, we synthesized and assessed a series of half-curcumin probes, among which demonstrated a high affinity and selectivity for Aβ aggregates.
View Article and Find Full Text PDFEgypt J Immunol
January 2025
Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
The autoimmune disease systemic lupus erythematosus (SLE) is presented with many clinical symptoms. The transcription factor fork head box protein 3 (Foxp3) is expressed on regulatory T (T-reg) cells and essential for its development and function. Functional single-nucleotide polymorphisms (SNPs) in the Foxp3-3279 (rs3761548 C/A) gene influence SLE pathogenesis.
View Article and Find Full Text PDFEgypt J Immunol
January 2025
Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.
Multiple sclerosis (MS) is a disease of the central nervous system, characterized by progressive demyelination and inflammation. MS is characterized by immune system attacks on the myelin sheath surrounding nerve fibers. Genome-wide association studies revealed a polymorphism in the signal transducer and activator of transcription 4 (STAT4) gene that increases risk for MS.
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