AI Article Synopsis
- Progressive multifocal leukoencephalopathy (PML) is a serious brain disease caused by the reactivation of the JC virus, primarily affecting those with weakened immune systems, like patients with HIV or those on immunosuppressive drugs.
- PML has been infrequently reported in multiple myeloma patients, and there's limited understanding of how it presents and progresses in this group.
- This study examines six cases of PML in multiple myeloma patients treated at the researchers' institution from 2013 to 2022, highlighting two cases that occurred after the patients received new BCMA-directed immunotherapies.
Article Abstract
Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal demyelinating disease of the central nervous system caused by reactivation of the JC virus in the context of immune suppression such as HIV, malignancy, and certain immunomodulatory medications. PML has been reported only rarely in multiple myeloma patients, and its presenting features and natural history in this population are not well known. We describe six cases of PML among multiple myeloma patients treated at our institution between 2013 and 2022, including two that developed on or shortly after treatment with recently developed BCMA-directed immunotherapies.
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| http://dx.doi.org/10.1111/ejh.13909 | DOI Listing |
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