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Unraveling the transcriptomic landscape of brain vascular cells in dementia: A systematic review.
Alzheimers Dement
January 2025
UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK.
Introduction: Cerebrovascular dysfunction plays a critical role in the pathogenesis of dementia and related neurodegenerative disorders. Recent omics-driven research has revealed associations between vascular abnormalities and transcriptomic alterations in brain vascular cells, particularly endothelial cells (ECs) and pericytes (PCs). However, the impact of these molecular changes on dementia remains unclear.
View Article and Find Full Text PDFCombined transcriptomic and metabolomic analyses reveal the pharmacognostic mechanism of the metabolism of flavonoids in different parts of Polygonum capitatum.
Plant Genome
March 2025
Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
The plant Polygonum capitatum (P. capitatum) contains a variety of flavonoids that are distributed differently among different parts. Nevertheless, differentially expressed genes (DEGs) associated with this heterogeneous distribution have not been identified.
View Article and Find Full Text PDFNovel insights into mechanisms and therapeutics for presbycusis.
Heliyon
January 2025
Department of Laboratory Medicine, Fujian Medical University, Fuzhou, 350122, China.
Presbycusis, also referred to as age-related hearing loss, poses a substantial burden on both individuals and society. The hallmark of presbycusis is a progressive decrease in auditory sensitivity. Irreversible hearing loss occurs due to the limited regenerative capacity of spiral neurons and peripheral cochlear hair cells (HCs).
View Article and Find Full Text PDFSynthesis, characterization, and application of MnFeO/FeVO/modified zeolite nanocomposite as an effective photocatalyst for methylene blue degradation and benzothiophene desulfurization.
Heliyon
January 2025
Department of Nanotechnology, Faculty of New Sciences and Technologies, Semnan University, Semnan, Iran.
This study details the synthesis of a novel ternary nanocomposite composed of MnFeO, FeVO, and modified zeolite, achieved through a two-step process. The initial step involved the hydrothermal synthesis of the MnFeO/FeVO composite, followed by its application onto modified zeolite using ultrasonic waves. The synthesized nanocomposite was thoroughly characterized using a range of analytical techniques.
View Article and Find Full Text PDFA Probabilistic Liquefaction Hazard Analysis: Case Studies from the Marmara Region.
Geotech Geol Eng (Dordr)
January 2025
School of Mechanical, Aerospace and Civil Engineering, The University of Sheffield, Sheffield, UK.
Earthquake induced soil liquefaction poses a significant threat to buildings and infrastructure, as evidenced by numerous catastrophic seismic events. Existing approaches of regional liquefaction hazard assessment predominantly rely on deterministic analysis methods. This paper presents a novel Probabilistic Liquefaction Hazard Analysis (PLHA) framework based on Monte-Carlo (MC) simulations to mitigate future seismic risks associated with liquefaction.
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